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SCP0137

Sigma-Aldrich

Endothelin Receptor Antagonist W 7338A

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About This Item

Empirical Formula (Hill Notation):
C30H42N6O7
Molecular Weight:
598.69
UNSPSC Code:
12352200
NACRES:
NA.32

Assay

≥95% (HPLC)

form

lyophilized

composition

Peptide Content, ≥85%

storage condition

protect from light

storage temp.

−20°C

Amino Acid Sequence

Glu-Ala-Val-Leu-Trp

Application

Endothelin Receptor Antagonist W-7338A isolated from Streptomyces sp. No. 7338 is used as an endothelin receptor antagonist.

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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S Miyata et al.
The Journal of antibiotics, 45(1), 83-87 (1992-01-01)
WS-7338, produced by Streptomyces sp. No. 7338, was found to be a competitive and specific antagonist against ET-1 receptors in in vitro studies and WS-7338 B is also active in vivo. Furthermore, WS-7338 B was a specific antagonist for vascular
WS-7338, new endothelin receptor antagonists isolated from Streptomyces sp. No. 7338. III. Structures of WS-7338 A, B, C and D and total synthesis of WS-7338 B.
S Miyata et al.
The Journal of antibiotics, 45(5), 788-791 (1992-05-01)
S Miyata et al.
The Journal of antibiotics, 45(1), 74-82 (1992-01-01)
WS-7338 A, B, C and D, novel endothelin receptor antagonists, have been isolated from fermentation broth of Streptomyces sp. No. 7338. These antagonists were purified from the culture mycelium by extraction with acetone, followed by carbon column chromatography and HPLC.
Javed Iqbal et al.
Mini reviews in medicinal chemistry, 5(4), 381-408 (2005-04-28)
Endothelins (ETs) are potent vasoconstrictor peptides and are associated with several disease states like pulmonary hypertension, systemic hypertension and heart failure. Endothelin-1 (ET-1) is the first member of the family and it has the receptor subtypes known as ETA and

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