S4197

Anti-Sirt6 (C-terminal) antibody produced in rabbit

~1 mg/mL, affinity isolated antibody, buffered aqueous solution

• Synonym(s): Anti-NAD-dependent deacetylase sirtuin 6, Anti-SIR2-like protein 6, Anti-SIR2L6
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen ~40 kDa
• species reactivity: human
• concentration: ~1 mg/mL
• technique(s): indirect immunofluorescence: suitable; western blot: 0.5-1 μg/mL using whole extracts of human U87 cells; western blot: 2.5-5 μg/mL using human HeLa cells
• UniProt accession no.: Q8N6T7
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... SIRT6(51548)

Description

General description

Sirtuin 6 (Sirt6) is a nuclear, chromatin-associated protein. Sirt6 is a member of Sir2 gene family. It is broadly expressed with the highest levels in muscle, brain and heart.

Immunogen

synthetic peptide corresponding to amino acids 330-348 of human Sirt6.

Application

Anti-Sirt6 (C-terminal) antibody has been used in

• immunoblotting
• immunofluorescence
• western blotting
• immunohistochemistry

Biochem/physiol Actions

Sirtuin 6 (Sirt6) plays a key role in DNA repair and maintenance of genomic stability in cells. Sirt6 is enzymatically inactive as a NAD⁺ -dependent protein deacetylase but displays auto-ADP-ribosyltransferase activity. Loss of Sirt6 leads to the development of an acute degenerative aging-like phenotype.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves