Skip to Content
Merck
All Photos(1)

Key Documents

More Documents

M9656

Sigma-Aldrich

H-8 dihydrochloride

>98% (HPLC)

Synonym(s):

N-[2-(Methylamino)ethyl]-5-isoquinolinesulfonamide hydrochloride

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C12H15N3O2S · 2HCl
CAS Number:
113276-94-1
Molecular Weight:
338.25
MDL number:
MFCD00036962
UNSPSC Code:
12352200
PubChem Substance ID:
24278039
NACRES:
NA.77

Quality Level

100

Assay

>98% (HPLC)

form

powder

storage temp.

2-8°C

SMILES string

Cl[H].Cl[H].CNCCNS(=O)(=O)c1cccc2cnccc12

InChI

1S/C12H15N3O2S.2ClH/c1-13-7-8-15-18(16,17)12-4-2-3-10-9-14-6-5-11(10)12;;/h2-6,9,13,15H,7-8H2,1H3;2*1H

InChI key

RJJLZYZEVNCZIW-UHFFFAOYSA-N

Gene Information

human ... CALCRL(10203) , PRKAR1A(5573) , PRKAR1AP(5574) , PRKAR1B(5575) , PRKAR2A(5576) , PRKAR2B(5577)
rat ... Calcrl(25029)

Biochem/physiol Actions

cAMP and cGMP-dependent protein kinase inhibitor.

Features and Benefits

This compound is featured on the PKA & PKG page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

F Shirakawa et al.
Molecular and cellular biology, 9(6), 2424-2430 (1989-06-01)
We have examined whether a precursor form of NF-kappa B, a DNA-binding protein that plays a role in the transcriptional control of several genes, including kappa immunoglobulin light chain and interleukin-2 receptor alpha subunit, could be activated in vitro by
Guijin Ma et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 131, 110766-110766 (2020-11-07)
Chrysin, a natural flavonoid available in honey, propolis and medicinal plants, has been shown to be vasorelaxant in some vascular beds. Proper intake of an alimental vasodilator as a food additive may be a promising strategy for prevention and treatment
H Hidaka et al.
Biochemistry, 23(21), 5036-5041 (1984-10-09)
Naphthalenesulfonamides such as N-(6-amino-hexyl)-5-chloro-1-naphthalenesulfonamide (W-7) are potent calmodulin (CaM) antagonists and act upon several protein kinases at higher concentration. When the naphthalene ring was replaced by isoquinoline, the derivatives were no longer CaM antagonists but retained the ability to inhibit

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service