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Merck

A9525

Sigma-Aldrich

Angiotensin II human

≥93% (HPLC), powder

Synonym(s):

1-8-AngiotensinI, 5-Isoleucine-angiotensinII, Ang II, Angiotensin 2, Angiotensin II, DRVYIHPF, Hypertensin, Ile(5)-angiotensinII

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5000 MG
€54.30

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5000 MG
€54.30

About This Item

Empirical Formula (Hill Notation):
C50H71N13O12
CAS Number:
Molecular Weight:
1046.18
MDL number:
UNSPSC Code:
12352202
eCl@ss:
42020611
PubChem Substance ID:
NACRES:
NA.32

€54.30


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To order products, please contact your local dealer.

biological source

synthetic

Quality Level

Assay

≥93% (HPLC)

form

powder

storage condition

(Keep container tightly closed in a dry and well-ventilated place)

concentration

≤100%

technique(s)

cell culture | mammalian: suitable

impurities

1.2-10.4% acetate

solubility

water: 25 mg/mL, clear, colorless

UniProt accession no.

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product line

BioReagent

product line

BioXtra

product line

-

product line

BioReagent

form

powder

form

lyophilized powder

form

powder

form

solution

technique(s)

cell culture | mammalian: suitable, single cell analysis: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | hybridoma: suitable

technique(s)

cell culture | mammalian: suitable, single cell analysis: suitable

shipped in

ambient

shipped in

ambient

shipped in

ambient

shipped in

ambient

Amino Acid Sequence

Asp-Arg-Val-Tyr-Ile-His-Pro-Phe

General description

Research area: Cell Signaling

Application

  • Angiotensin II (angII) human has been used:
  • to study its effect on interleukin-1β–mediated islet inflammation and β-cell dysfunction.[1]
  • to determine if angII activates specific calcineurin-dependent NFAT (nuclear factor of activated T-cells) isoforms in cardiomyocytes.[2]
  • to study the actions of systemic angII infusions on glomerular permeability in vivo.[3]
  • to induce abdominal aortic aneurysms (AAAs) in ApoE knockout mice for experimental studies.[4]
  • to study the effect of Ang II infusion on atrial branched-chain amino acids (BCAAs) catabolism in male C57/BL6 mice.[5]
  • to check the effects of angII on plasma triglyceride production and its association with insulin resistance in normal rats.[6]

Biochem/physiol Actions

Angiotensin II (angII) is an octapeptide cardiovascular[7] hormone which affects the activities of the heart, kidney, vasculature and brain. AngII in the blood is produced from angiotensinogen via renin and angiotensin converting enzyme (ACE). It works via binding to specific receptors present on cell membranes. It is associated with vasoconstriction, induction of vascular smooth muscle cell growth, stimulation of protooncogene expression, and modulation of myocardial hypertrophy, renal failure and fibrosis[8][9][10][11][12][13]AngII plays a key role in the regulation of blood pressure via the renin-angiotensin-aldosterone (RAAS) pathway.[14]

Features and Benefits

The purity of our angiotensin II human, Ang II, is verified to assure your experimental success (HPLC and peptide content). The peptide sequence is DRVYIHPF.

Antibody Adsorbant

Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-OH · 2CH3COOH · H2O

Analysis Note

Peptide content not less than 75%

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Xiang He et al.
Theranostics, 9(19), 5558-5576 (2019-09-20)
Objective: Long noncoding RNAs (lncRNAs) may serve as specific targets for the treatment of abdominal aortic aneurysms (AAAs). LncRNA GAS5, functionally associated with smooth muscle cell (SMC) apoptosis and proliferation, is likely involved in AAA formation, but the exact role
Angiotensin II cell signaling: physiological and pathological effects in the cardiovascular system.
Mehta PK and Griendling KK
American Journal of Physiology. Cell Physiology, 292, C82-C82 (2007)
B Erdmann et al.
Hypertension (Dallas, Tex. : 1979), 28(5), 818-824 (1996-11-01)
We localized angiotensin II (Ang II) immunoreactivity in the rat cerebellar cortex with immunogold staining methods. Perfusion fixation with high amounts of glutaraldehyde and the use of cryoultramicrotomy caused remarkable changes in immunostaining versus formaldehyde/picric acid fixation. With the use
Takumi Ota et al.
Molecular and cellular biology, 34(20), 3880-3894 (2014-08-06)
The 3β-hydroxysteroid dehydrogenase (3β-HSD) is an enzyme crucial for steroid synthesis. Two different 3β-HSD isoforms exist in humans. Classically, HSD3B2 was considered the principal isoform present in the adrenal. However, we recently showed that the alternative isoform, HSD3B1, is expressed
Angiotensin II induces interleukin-1?-mediated islet inflammation and ?-cell dysfunction independently of vasoconstrictive effects.
Sauter NS et al.
Diabetes, 64, 1273-1273 (2015)

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