8.52401
Fmoc-Asp(OEpe)-OH
Novabiochem®
Synonym(s):
Fmoc-Asp(OEpe)-OH, N-α-Fmoc-(O-3-ethyl-pent-3-yl)aspartic acid
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About This Item
Empirical Formula (Hill Notation):
C26H31NO6
Molecular Weight:
453.53
UNSPSC Code:
12352209
NACRES:
NA.22
Quality Level
product line
Novabiochem®
form
powder
reaction suitability
reaction type: Fmoc solid-phase peptide synthesis
manufacturer/tradename
Novabiochem®
application(s)
peptide synthesis
functional group
carboxylic acid
storage temp.
15-25°C
General description
An excellent derivative for minimizing aspartimide formation during Fmoc SPPS of Asp-containing peptides. The bulky OEpe protecting group offers considerably more protection against the formation of aspartimide-related by-products than the commonly used OtBu and OMpe group. The combination of Asp(OEpe) and the use of 1 M Oxyma Pure in DMF for Fmoc removal results in minimal aspartimde formation.
Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS
Overcoming Aspartimide Formation in Fmoc SPPS
Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS
Overcoming Aspartimide Formation in Fmoc SPPS
Analysis Note
Colour (visual): white to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Purity (DC (018A)): ≥ 95 %
Enantiomeric purity: ≥ 99.5 % (a/a)
Assay (HPLC, area%): ≥ 97.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clearly soluble
To see the solvent systems used for TLC of Novabiochem® products please click here.
Appearance of substance (visual): powder
Identity (IR): passes test
Purity (DC (018A)): ≥ 95 %
Enantiomeric purity: ≥ 99.5 % (a/a)
Assay (HPLC, area%): ≥ 97.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clearly soluble
To see the solvent systems used for TLC of Novabiochem® products please click here.
Legal Information
Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
11 - Combustible Solids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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