8.51028
Bis-Boc-amino-oxyacetic acid
Novabiochem®
Synonym(s):
Bis-Boc-amino-oxyacetic acid, Boc 2-Aoa-OH
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About This Item
Empirical Formula (Hill Notation):
C12H21NO7 · xH2O
Molecular Weight:
291.30 (anhydrous basis)
UNSPSC Code:
12352209
NACRES:
NA.22
Quality Level
product line
Novabiochem®
Assay
≥97% (TLC)
form
powder
reaction suitability
reagent type: ligand
manufacturer/tradename
Novabiochem®
application(s)
peptide synthesis
storage temp.
2-8°C
General description
This reagent can be used to introduce a hydroxylamine functionality to N-terminal or side-chain amino groups. Hydroxylamine-labeled peptides prepared in this manner can be ligated in aqueous solution at pH 3.5 to aldehyde-containing peptides via oxime formation. This bis-protected derivative eliminates oligomer formation which can occur with mono-protected hydroxylamine reagents as a result of double acylation. Coupling of this derivative should be done using an OSu ester.
Literature references
[1] J. C. Spetzler & T. Hoeg-Jensen (2001) J. Peptide Sci., 7, 537.
Literature references
[1] J. C. Spetzler & T. Hoeg-Jensen (2001) J. Peptide Sci., 7, 537.
Linkage
Replaces: 01-63-0129
Analysis Note
Colour (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Purity (TLC(CMA2)): ≥ 97 %
Water (K. F.): 3.0 - 8.0 %
To see the solvent systems used for TLC of Novabiochem® products please click here.
Appearance of substance (visual): powder
Identity (IR): passes test
Purity (TLC(CMA2)): ≥ 97 %
Water (K. F.): 3.0 - 8.0 %
To see the solvent systems used for TLC of Novabiochem® products please click here.
Legal Information
Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Certificates of Analysis (COA)
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