539522

PKC_ε Translocation Inhibitor Peptide

The PKC_ε Translocation Inhibitor Peptide, Negative Control controls the biological activity of PKC_ε. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• Synonym(s): PKC_ε Translocation Inhibitor Peptide, Protein Kinase Cε Translocation Inhibitor I, EAVSLKPT, PKCε Translocation Inhibitor I, PKCε-RACK2 Interaction Inhibitor I
• Empirical Formula (Hill Notation): C₃₇H₆₅N₉O₁₃
• Molecular Weight: 843.96
• UNSPSC Code: 12352202
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥97% (HPLC)
• form: lyophilized solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; desiccated (hygroscopic)
• color: white
• solubility: water: 3 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C

Description

General description

An octapeptide that selectively inhibits the translocation of PKC_ε to subcellular sites. Inhibition of PKC_ε translocation is known to specifically block phorbol ester or norepinephrine-mediated regulation of contraction in cardiomyocytes.

An octapeptide that selectively inhibits the translocation of protein kinase C_ε to subcellular sites in a reversible manner. Inhibition of PKC_ε translocation is known to specifically block phorbol ester- or norepinephrine-mediated regulation of contraction in cardiomyocytes.

Biochem/physiol Actions

Cell permeable: no

Primary Target
PKCε Translocation

Product does not compete with ATP.

Reversible: yes

Warning

Toxicity: Standard Handling (A)

Sequence

H-Glu-Ala-Val-Ser-Leu-Lys-Pro-Thr-OH

Physical form

Supplied as a trifluoroacetate salt.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C) for long-term storage. Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Yedovitzky, M., et al. 1997. J. Biol. Chem. 272, 1417.
Johnson, J.A., et al. 1996. J. Biol. Chem.271, 24962.

Legal Information

Sold under license of U.S. Patent 5,783,405.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable