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439533

Sigma-Aldrich

2,4,6-Tribromo-3-hydroxybenzoic acid

97%

Synonym(s):

3-Hydroxy-2,4,6-tribromobenzoic acid

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About This Item

Linear Formula:
HC6Br3(OH)CO2H
CAS Number:
14348-40-4
Molecular Weight:
374.81
MDL number:
MFCD00055557
UNSPSC Code:
12352100
PubChem Substance ID:
24867517
NACRES:
NA.22

Quality Level

100

Assay

97%

form

powder

mp

145-148 °C (lit.)

SMILES string

OC(=O)c1c(Br)cc(Br)c(O)c1Br

InChI

1S/C7H3Br3O3/c8-2-1-3(9)6(11)5(10)4(2)7(12)13/h1,11H,(H,12,13)

InChI key

YDBHVMTTYXWHLI-UHFFFAOYSA-N

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General description

2,4,6-Tribromo-3-hydroxybenzoicacid (TBHBA) is an organic compound used as a building block. TBHBA is an enzymic colorimetric reagent to determine the free cholesterol fraction of high-density lipoprotein (HDL) in plasma.

Application


  • One-pot synthesis and nano-bio applications: Research described a one-pot bottom-up synthesis technique for a 2D graphene derivative, utilizing 2,4,6-Tribromo-3-hydroxybenzoic acid, demonstrating its applications in biomolecular recognition and nanozyme activities (Pandit and De, 2021).

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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J S Moshides
Scandinavian journal of clinical and laboratory investigation, 48(1), 59-64 (1988-02-01)
A sensitive enzymatic method for the measurement of high density lipoprotein choline-containing phospholipids (HDL-pc) was adapted to a Cobas Bio Centrifugal Analyzer. The Boehringer Mannheim phospholipase D/choline oxidase/peroxidase reagent was modified by the inclusion of 2,4,6,-tribromo-3-hydroxybenzoic acid (TBHBA) which reacts
V Saroja Voruganti et al.
The American journal of clinical nutrition, 101(4), 725-732 (2015-04-04)
Elevated concentrations of serum uric acid are associated with increased risk of gout and renal and cardiovascular diseases. Genetic studies in adults have consistently identified associations of solute carrier family 2, member 9 (SLC2A9), polymorphisms with variation in serum uric
P Trinder et al.
Annals of clinical biochemistry, 21 ( Pt 5), 430-433 (1984-09-01)
The Boehringer one-component high-performance cholesterol oxidase reagent has been modified by the inclusion of 2,4,6-tribromo-3-hydroxybenzoic acid (TBHBA) to give a fourfold increase in sensitivity to a molar absorbance of approximately equal to 29,000 with respect to cholesterol. The resulting reagent
J S Moshides
Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie, 25(9), 583-587 (1987-09-01)
A sensitive fixed-time kinetic enzymatic method for the measurement of high density lipoprotein cholesterol is described, as adapted for the Cobas Bio centrifugal analyser (Hoffmann LaRoche). The Boehringer Mannheim cholesterol esterase/cholesterol oxidase/peroxidase/3,4-dichlorophenol kinetic reagent was modified by the inclusion of
J S Moshides
Clinical chemistry, 34(9), 1799-1804 (1988-09-01)
A highly sensitive enzymic colorimetric reagent is described for determination of the free cholesterol fraction of high-density lipoprotein (HDL), which represents about 20% of the total cholesterol content of this lipoprotein. For greater sensitivity with respect to cholesterol, I used
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