284297
2-Mercaptoimidazole
98%
Synonym(s):
2-Imidazolethiol
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About This Item
Empirical Formula (Hill Notation):
C3H4N2S
CAS Number:
Molecular Weight:
100.14
Beilstein:
105775
EC Number:
MDL number:
UNSPSC Code:
12352005
PubChem Substance ID:
NACRES:
NA.22
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Assay
98%
form
solid
mp
228-231 °C (lit.)
solubility
methanol: soluble 50 mg/mL, clear to slightly hazy, colorless to yellow
SMILES string
Sc1ncc[nH]1
InChI
1S/C3H4N2S/c6-3-4-1-2-5-3/h1-2H,(H2,4,5,6)
InChI key
OXFSTTJBVAAALW-UHFFFAOYSA-N
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General description
The kinetics of inhibition on mushroom tyrosinase by 2-mercaptoimidazole has been investigated. The pH dependent surface-enhanced Raman scattering (SERS) spectra of biologically and industrially significant, 2-mercaptoimidazole molecule at 1.0×10-10M concentration have been investigated.
Application
2-Mercaptoimidazole has been used in chemical modification of silica gel for selective separation of mercury(II) from an aqueous solution.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Target Organs
Respiratory system
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Subhendu Chandra et al.
Journal of colloid and interface science, 399, 33-45 (2013-04-02)
The pH dependent surface-enhanced Raman scattering (SERS) spectra of biologically and industrially significant, 2-mercaptoimidazole (2-MI) molecule at 1.0×10(-10)M concentration have been investigated. The pH dependent SERS spectra are compared with the corresponding normal Raman spectra (NRS) of the molecule. The
Chin-Feng Chan et al.
Bioorganic & medicinal chemistry, 22(9), 2809-2815 (2014-04-08)
In this study, we synthesized 4 methimazole (2-mercapto-1-methylimidazole, MMI) derivatives. The kinetics of inhibition on mushroom tyrosinase by methimazole and its derivatives were investigated. The results indicated that tert-butyl 3-methyl-2-sulfanylidene-2,3-dihydro-1H-imidazole-1-carboxylate (compound 3; 3), 2-mercaptoimidazole (MI; compound 1; 1) and MMI
2-Mercaptoimidazole covalently bonded to a silica gel surface for the selective separation of mercury (II) from an aqueous solution.
Filho NLD and Gushikem Y.
Separation Science and Technology, 32(15), 2535-2545 (1997)
Lívia P L Matos et al.
Clinical and experimental pharmacology & physiology, 45(4), 326-334 (2017-11-08)
Na+ /I- symporter (NIS) transports iodide into thyrocytes, a fundamental step for thyroid hormone biosynthesis. Our aim was to evaluate NIS regulation in different status of goitrogenesis and its underlying mechanisms. Wistar rats were treated with methimazole (MMI) for 5
Guy Van Lomen et al.
Bioorganic & medicinal chemistry letters, 15(3), 497-500 (2005-02-26)
We describe the synthesis and SAR of a new class of CCR2 antagonists based on 2-mercaptoimidazole scaffold. The initial lead 1a was optimized to the 3,4-disubstituted analogues 1p-(S) and 1q-(S), which have IC(50) values in the MCP-1 induced Ca-flux below
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