- Bulky trialkylsilyl acetylenes in the Cadiot-Chodkiewicz cross-coupling reaction.
Bulky trialkylsilyl acetylenes in the Cadiot-Chodkiewicz cross-coupling reaction.
The Journal of organic chemistry (2002-09-14)
Joseph P Marino, Hanh Nho Nguyen
PMID12227823
초록
Bulky trialkylsilyl-protected alkynes such as triethylsilyl (TES), tert-butyldimethylsilyl (TBS), and triisopropylsilyl (TIPS) acetylenes underwent the Cadiot-Chodkiewicz cross-coupling reaction with different bromoalkynes to form a variety of synthetically useful unsymmetrical diynes in good yields. The diyne alcohol 10 was transformed regio- and stereoselectively into enynes by hydrotelluration, carbometalation, and reduction reactions.