- Models of binding of 4'-nitrophenyl alpha-D-mannopyranoside to the lectin concanavalin A.
Models of binding of 4'-nitrophenyl alpha-D-mannopyranoside to the lectin concanavalin A.
International journal of biological macromolecules (1989-02-01)
S J Hamodrakas, E Alexandraki, A Troganis, C I Stassinopoulou
PMID2489052
초록
Molecular models for the complex formed between the lectin concanavalin A (Con A) and the saccharide derivative 4'-nitrophenyl-alpha-D-mannopyranoside (alpha-PNM) are presented, combining evidence from 1H-n.m.r. measurements, semi-empirical energy calculations and interactive graphics modelling. The models are in good agreement with the experimental data. Close examination of the models suggests that hydrophobic interactions together with van der Waals interactions and hydrogen bonds contribute to the stability of the complexes. It appears that there is a limited number of possible modes of binding of alpha-PNM to Con A.
MATERIALS