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Merck
  • An investigation of the ionophoric characteristics of destruxin A.

An investigation of the ionophoric characteristics of destruxin A.

Archives of biochemistry and biophysics (2002-08-15)
Maria Hinaje, Martyn Ford, Lee Banting, Steve Arkle, Bhupinder Khambay
초록

Destruxin A, a cyclohexadepsipeptide related to the enniatins and beauvericin, exhibits ionophoric properties. Calcium ion mobilization across liposomal membrane barriers, for example, has been demonstrated using the calcium ion-sensitive dyes Arsenazo III and Fura-2. Initial molecular mechanics/molecular dynamics calculations indicate the potential for destruxin A to form a coordination complex with calcium in which the divalent cation is bound at the center of a sandwich formed by two molecules of destruxin A. This novel calcium ion binding may help explain the diverse biological effects exhibited by the destruxins.

MATERIALS
제품 번호
브랜드
제품 설명

Sigma-Aldrich
Destruxin A from Metarrhizium anisopliae, ≥98% (HPLC)
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