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Merck
  • Improved synthesis of C-terminal peptide thioesters on "safety-catch" resins using LiBr/THF.

Improved synthesis of C-terminal peptide thioesters on "safety-catch" resins using LiBr/THF.

Organic letters (2001-09-28)
R Quaderer, D Hilvert
초록

[reaction: see text] The alkanesulfonamide "safety-catch" resin has proven useful for Fmoc-based synthesis of C-terminal peptide thioesters. We now report that the yield of isolated thioester can increase significantly when the cleavage reaction is carried out in 2 M LiBr/THF rather than DMF or THF. The largest effects are seen with problematic peptides that aggregate or form secondary structures on the resin.

MATERIALS
제품 번호
브랜드
제품 설명

Sigma-Aldrich
Lithium bromide solution, 54 wt. % in H2O
Sigma-Aldrich
Lithium bromide, powder and chunks, ≥99.995% trace metals basis
Sigma-Aldrich
Lithium bromide, ReagentPlus®, ≥99%
Sigma-Aldrich
Lithium bromide, AnhydroBeads, −10 mesh, ≥99.9% trace metals basis
Sigma-Aldrich
Lithium bromide, AnhydroBeads, −10 mesh, 99.999% trace metals basis