Y0002299

Nebivolol hydrochloride

CRS, European Pharmacopoeia (EP) Reference Standard

• 동의어(들): Narbivolol, Nebilet, R-65824, rel-(aR,a′R,2R,2′S)-a,a′-[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol] hydrochloride
• 실험식(Hill 표기법): C₂₂H₂₅F₂NO₄ · HCl
• CAS Number: 152520-56-4
• Molecular Weight: 441.90
• UNSPSC 코드: 41116107
• NACRES: NA.24

속성

• Grade: pharmaceutical primary standard
• API family: nebivolol
• 제조업체/상표: EDQM
• 저장 온도: 2-8°C
• SMILES string: Cl.O[C@@H](CNC[C@H](O)[C@@H]1CCc2cc(F)ccc2O1)[C@H]3CCc4cc(F)ccc4O3
• InChI: 1S/C22H25F2NO4.ClH/c23-15-3-7-19-13(9-15)1-5-21(28-19)17(26)11-25-12-18(27)22-6-2-14-10-16(24)4-8-20(14)29-22;/h3-4,7-10,17-18,21-22,25-27H,1-2,5-6,11-12H2;1H/t17-,18-,21-,22+;/m0./s1
• InChI key: JWEXHQAEWHKGCW-BIISKSHESA-N

설명

일반 설명

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

애플리케이션

Nebivolol hydrochloride EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

생화학적/생리학적 작용

Nebivolol is a competitive, highly selective b1-receptor antagonist with mild vasodialating properties, possibly due to an interaction with the L-arginine/ NO pathway, and is used for treatment of essential hypertension. It is 40-fold selective for β1 vs. β2, and lacks ISA (intrinsic sympathomimetic activity).

포장

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

기타 정보

Sales restrictions may apply.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3