Z3777

ZD7288 hydrate

≥98% (HPLC)

• 동의어(들): 4-(N-Ethyl-N-phenylamino)-1,2 dimethyl-6-(methylamino) pyrimidinium chloride, ICI-D7288, N-Ethyl-1,6-dihydro-1,2-dimethyl-6-(methylimino)-N-phenyl-4-pyrimidinamine hydrochloride, ZD 7288
• 실험식(Hill 표기법): C₁₅H₂₀N₄ · HCl · xH₂O
• Molecular Weight: 292.81 (anhydrous basis)
• MDL number: MFCD16879001
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329831610
• NACRES: NA.77

속성

• 분석: ≥98% (HPLC)
• 형태: powder
• 저장 조건: desiccated
• 색상: white to beige
• solubility: DMSO: 10 mg/mL, clear
• 주관자: AstraZeneca
• 저장 온도: 2-8°C
• SMILES string: O.Cl.CCN(c1ccccc1)C2=CC(=N/C)\N(C)C(C)=N2
• InChI: 1S/C15H20N4.ClH.H2O/c1-5-19(13-9-7-6-8-10-13)15-11-14(16-3)18(4)12(2)17-15;;/h6-11H,5H2,1-4H3;1H;1H2/b16-14+;;
• InChI key: NCEDDDWQLCMZQG-UPONXUSQSA-N

설명

애플리케이션

ZD7288 hydrate has been used as I_h blocker to study its effect on
neocortical tissue. It has been used as hyperpolarization-activated and cyclic nucleotide-gated (HCN)-channel blocker to test the involvement of HCN channels in the phototransduction pathway.

생화학적/생리학적 작용

Selective blocker of cation channel Ih; If blocker and sino-atrial node function modulator, blocks hyperpolarization-activated and cyclic nucleotide-gated (HCN) channels.

ZD7288 can block hippocampal synaptic plasticity.

특징 및 장점

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Cyclic Nucleotide-Gated (CNG) and Hyperpolarization Activated Cyclic Nucleotide-Gated (HCN) Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable