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Merck
모든 사진(5)

Key Documents

WH0004790M1

Sigma-Aldrich

Monoclonal Anti-NFKB1 antibody produced in mouse

clone 2E6, purified immunoglobulin, buffered aqueous solution

동의어(들):

Anti-DKFZp686C01211, Anti-EBP1, Anti-KBF1, Anti-MGC54151, Anti-NFKBp105, Anti-NFKBp50, Anti-NFkappaB, Anti-nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105)

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모든 사진(5)

About This Item

MDL number:
MFCD00802846
UNSPSC 코드:
12352203
NACRES:
NA.41

생물학적 소스

mouse

Quality Level

100

결합

unconjugated

항체 형태

purified immunoglobulin

항체 생산 유형

primary antibodies

클론

2E6, monoclonal

형태

buffered aqueous solution

종 반응성

human

기술

indirect ELISA: suitable
indirect immunofluorescence: suitable
proximity ligation assay: suitable
western blot: 1-5 μg/mL

동형

IgG1κ

GenBank 수납 번호

BC051765

UniProt 수납 번호

P19838

배송 상태

dry ice

저장 온도

−20°C

타겟 번역 후 변형

unmodified

유전자 정보

human ... NFKB1(4790)

일반 설명

NFKB1 (nuclear factor κB subunit 1) is a dimeric transcription factor. It belongs to the REL family. This gene is located on human chromosome 4q24.

면역원

NFKB1 (AAH51765, 860 a.a. ~ 969 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
MDNYEVSGGTVRELVEALRQMGYTEAIEVIQAASSPVKTTSQAHSLPLSPASTRQQIDELRDSDSVCDSGVETSFRKLSFTESLTSGASLLTLNKMPHDYGQEGPLEGKI

생화학적/생리학적 작용

NFKB1 (nuclear factor κB subunit 1) controls the maturation of NK (natural killer) cells and effector functions. This gene helps in the upregulation of intrauterine adhesion inflammatory factors, hence NFKB1 plays a major role in inflammatory diseases.

물리적 형태

Solution in phosphate buffered saline, pH 7.4

법적 정보

GenBank is a registered trademark of United States Department of Health and Human Services

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

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문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

EBV induces persistent NF-?B activation and contributes to survival of EBV-positive neoplastic T- or NK-cells
Takada H, et al.
PLoS ONE, 12(3) (2017)
NFKB1 regulates human NK cell maturation and effector functions
Lougaris V, et al.
Clinical Immunology (Orlando, Fla.) (2017)
Elevated NF-?B signaling in Asherman syndrome patients and animal models
Wang X, et al.
Oncotarget, 8(9), 15399-15406 (2017)
J Spring
FEBS letters, 400(1), 2-8 (1997-01-02)
For the growing fraction of human genes with identified functions there are often homologues known from invertebrates such as Drosophila. A survey of well established gene families from aldolases to zinc finger transcription factors reveals that usually a single invertebrate
Y Yu et al.
British journal of cancer, 111(3), 515-524 (2014-06-13)
Ovarian cancer has the highest mortality rate of the gynaecological cancers. Although cisplatin (CDDP) is an effective treatment for ovarian cancer, recurrence is frequent and leads to death. The objective was to explore the role and possible mechanisms of platelet-activating
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