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Merck
모든 사진(1)

Key Documents

UC432

Sigma-Aldrich

AAMU

동의어(들):

5-Acetylamino-6-amino-3-methyluracil, N-(4-Amino-1,2,3,6-tetrahydro-1-methyl-2,6-dioxo-5-pyrimidinyl)acetimide

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About This Item

실험식(Hill 표기법):
C7H10N4O3
CAS Number:
Molecular Weight:
198.18
MDL number:
UNSPSC 코드:
12161501
PubChem Substance ID:
NACRES:
NA.77

형태

solid

색상

white to light pink

mp

≥305 °C

저장 온도

2-8°C

SMILES string

CN1C(=O)NC(N)=C(NC(C)=O)C1=O

InChI

1S/C7H10N4O3/c1-3(12)9-4-5(8)10-7(14)11(2)6(4)13/h8H2,1-2H3,(H,9,12)(H,10,14)

InChI key

POQOTWQIYYNXAT-UHFFFAOYSA-N

애플리케이션

CYP1A2 metabolite of caffeine

포장

Bottomless glass bottle. Contents are inside inserted fused cone.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)


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문서 라이브러리 방문

Y Kawakubo et al.
Dermatology (Basel, Switzerland), 195(1), 43-45 (1997-01-01)
p-Phenylenediamine (PPD) has been widely distributed as hair dye ingredient and may be responsible for contact dermatitis. Since not all the subjects exposed to PPD react to the substance, we tested a possible predisposing factor of cutaneous drug metabolism. Eighty-five
P Wong et al.
Journal of pharmaceutical and biomedical analysis, 13(9), 1079-1086 (1995-08-01)
The ratio of 5-acetylamino-6-amino-3-methyluracil (AAMU) to 1-methylxanthine (1X) in urine samples after caffeine ingestion can be used to indicate human N-acetyltransferase (NAT2) phenotypes. In previous studies, this ratio has been determined by LC or capillary electrophoresis. The possibility that this
B K Tang et al.
Clinical pharmacology and therapeutics, 49(6), 648-657 (1991-06-01)
The use of two caffeine metabolite ratios for acetylator phenotyping was validated by demonstrating concordance with two sulfamethazine tests in 178 unrelated healthy subjects. The caffeine metabolites used for this purpose were 5-acetylamino-6-amino-3-methyluracil (AAMU), 1-methylxanthine (1X), and 1-methylurate (1U). The
B K Tang et al.
Clinical pharmacology and therapeutics, 42(5), 509-513 (1987-11-01)
Previously published methods allow the determination of the genetically controlled acetylator status using caffeine as a test drug, based on the urinary excretion of a ring-opened metabolite of caffeine, an acetylated uracil (5-acetylamino-6-formylamino-3-methyluracil). 5-Acetylamino-6-formylamino-3-methyluracil is labile but can be converted
A J Kilbane et al.
Clinical pharmacology and therapeutics, 47(4), 470-477 (1990-04-01)
The human acetylation genotype was determined by measuring urinary caffeine metabolites by use of a modification of a previously published HPLC method. The problem of separation of 7-methylxanthine (7X) from 1-methyluric acid (IU) in urine extracts was achieved by adding

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