재조합
expressed in E. coli
Quality Level
분석
≥95% (SDS-PAGE)
양식
liquid
분자량
18 kDa
배송 상태
dry ice
저장 온도
−70°C
유전자 정보
human ... UBE2G2(7327) , UBE2L3(7332)
일반 설명
Manufactured for Sigma by Boston Biochem., Inc.
생화학적/생리학적 작용
Acts in conjunction with Ubc6 to degrade MAT α2 factor.
May act in both the degradation of non-N-end rule protein substrates and of certain Nα-acetylated proteins as well as the degradation of tumor suppressor protein p53.
물리적 형태
Solution in 50 mM HEPES, pH 8.0, 50 mM NaCl, 1 mM DTT in 10% glycerol.
Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 2
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
P Chen et al.
Cell, 74(2), 357-369 (1993-07-30)
Attachment of ubiquitin to proteins is catalyzed by a family of ubiquitin-conjugating (UBC) enzymes. Although these enzymes are essential for many cellular processes; their molecular functions remain unclear because no physiological target has been identified for any of them. Here
Jian Wang et al.
The Journal of biological chemistry, 285(16), 12279-12288 (2010-02-23)
Nedd4 E3 ligases are members of the HECT E3 ubiquitin ligase family and regulate ubiquitination-mediated protein degradation. In this report, we demonstrate that calcium releases the C2 domain-mediated auto-inhibition in both Nedd4-1 and Nedd4-2. Calcium disrupts binding of the C2
Evangelia Koutelou et al.
The Journal of biological chemistry, 283(7), 3846-3853 (2007-12-14)
Notch signaling constitutes an evolutionarily conserved mechanism that mediates cell-cell interactions in various developmental processes. Numerous regulatory proteins interact with the Notch receptor and its ligands and control signaling at multiple levels. Ubiquitination and endocytosis followed by endosomal sorting of
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