U109
R(+)-UH-301 hydrochloride
solid
동의어(들):
R(+)-5-Fluoro-8-Hydroxy-DPAT hydrochloride, R(+)-5-Fluoro-8-hydroxy-2-dipropylamino-1,2,3,4-tetrahydronaphthalene hydrochloride
로그인조직 및 계약 가격 보기
모든 사진(1)
About This Item
실험식(Hill 표기법):
C16H24FNO · HCl
CAS Number:
Molecular Weight:
301.83
MDL number:
UNSPSC 코드:
12352202
PubChem Substance ID:
NACRES:
NA.77
추천 제품
양식
solid
광학 활성
[α]25/D +81.4°, c = 0.30 in methanol(lit.)
색상
white
solubility
H2O: slightly soluble
ethanol: soluble
SMILES string
Cl[H].CCCN(CCC)[C@@H]1CCc2c(F)ccc(O)c2C1
InChI
1S/C16H24FNO.ClH/c1-3-9-18(10-4-2)12-5-6-13-14(11-12)16(19)8-7-15(13)17;/h7-8,12,19H,3-6,9-11H2,1-2H3;1H/t12-;/m1./s1
InChI key
FKUVCCNCUAFKAH-UTONKHPSSA-N
유전자 정보
human ... HTR1A(3350)
생화학적/생리학적 작용
R(+)-UH-301 hydrochloride is a potent and selective 5-HT1A serotonin receptor agonist. R(+)-UH-301 is also known to function as an antinociceptive agent, as it has been shown to significantly decrease formalin-induced flinching in rats.
주의사항
Hygroscopic, photosensitive
제조 메모
R(+)-UH-301 hydrochloride is soluble in ethanol and is slightly soluble in water.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, type N95 (US)
가장 최신 버전 중 하나를 선택하세요:
L Björk et al.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2(2), 141-147 (1992-06-01)
The effects of the enantiomers of 5-fluoro-8-hydroxy-2-(dipropylamino)tetralin, UH-301 and the potent 5-HT1A-receptor agonist (R)-8-hydroxy-2-(dipropylamino)tetralin, (R)-8-OH-DPAT, on locomotion, rearing and total activity were studied in rats. The experiments were performed as tests either of exploratory activity in non-habituated rats or of
Y Minabe et al.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2(2), 127-133 (1992-06-11)
In this study, we examined the effects of acute and chronic administration of the 5-HT3 receptor antagonist granisetron (0.1, 1.0 or 10 mg/kg i.p.) alone or in combination with haloperidol (0.5 mg/kg i.p.) on the number of spontaneously active dopamine
V Granados-Soto et al.
Neuroscience, 165(2), 561-568 (2009-10-20)
This study assessed the possible antinociceptive role of peripheral 5-HT(1) receptor subtypes in the rat formalin test. Rats were injected into the dorsum of the hind paw with 50 microl of diluted formalin (1%). Nociceptive behavior was quantified as the
Phedias Diamandis et al.
Nature chemical biology, 3(5), 268-273 (2007-04-10)
The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways that governs the
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