T5705

Terrein

from Aspergillus terreus, ≥98% (HPLC)

• 동의어(들): (+)Terrein, Terrain
• 실험식(Hill 표기법): C₈H₁₀O₃
• CAS Number: 582-46-7
• Molecular Weight: 154.16
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• 생물학적 소스: Aspergillus terreus
• Quality Level: 200
• 분석: ≥98% (HPLC)
• 저장 조건: protect from light
• solubility: H₂O: soluble 1-1.10 mg/mL, clear, colorless; DMSO: soluble
• 저장 온도: −20°C
• InChI: 1S/C8H10O3/c1-2-3-5-4-6(9)8(11)7(5)10/h2-4,7-8,10-11H,1H3/b3-2+
• InChI key: MHOOPNKRBMHHEC-NSCUHMNNSA-N

설명

생화학적/생리학적 작용

Terrein is a bioactive fungal metabolite that has plant growth inhibition and antibacterial activities. Terrein reduces melanin levels in a dose-dependent manner as well as tyrosinase protein production. In mammals, there are three melanocyte-specific enzymes: tyrosinase, tyrosinase-related protein-1 (TRP-1), and TRP-2 that are involved in tyrosine conversion into melanin (melanogenesis). Terrein inhibits melanin synthesis by reducing tyrosinase production via extracellular signal-regulated protein kinase (ERK) activation. ERK activation is followed by microphthalmia-associated transcription factor (MITF) down regulation, which is required for tyrosinase expression.

제조 메모

Terrein is soluble in water at 1-1.10 mg/ml and yields a clear, colorless solution. It is also soluble in DMSO. Hence, the product may be reconstituted in water or DMSO.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable