SRP8043

APRIL, Soluble mouse

recombinant, expressed in HEK 293 cells, FLAG^® tagged, >95% (SDS-PAGE)

• 동의어(들): ACRP30headless:A-proliferation-inducing ligand, ACRP30headless:APRIL, ACRP30headless:CD256, TNFSF10
• UNSPSC 코드: 12352200
• NACRES: NA.32

속성

• 생물학적 소스: mouse
• 재조합: expressed in HEK 293 cells
• 태그: FLAG^® tagged
• 분석: >95% (SDS-PAGE)
• 양식: lyophilized
• 분자량: ~34 kDa by SDS-PAGE
• 포장: pkg of 10 μg
• 저장 조건: avoid repeated freeze/thaw cycles
• 불순물: <0.02 EU/μg endotoxin, tested
• 색상: white
• UniProt 수납 번호: Q9D777
• 배송 상태: wet ice
• 저장 온도: −20°C
• 유전자 정보: mouse ... Tnfsf13(69583)

설명

일반 설명

APRIL is a cytokine that belongs to the TNF superfamily and binds to TACI and BCMA. It is implicated in the regulation of tumor cell growth, is involved in monocyte/macrophage-mediated immunological processes and functions as an important survival factor for plasmablasts and bone marrow plasma cells. APRIL is a high activity construct in which two trimeric APRIL ligands are artificially linked via the collagen domain of ACRP30. This construct very effectively stimulates proliferation B cell. A basic amino acid sequence (QKQKKQ) close to the N-terminus of APRIL is required for binding to negatively charged sulfated glycosaminoglycan side chains of proteoglycans. Proteoglycans mediate binding of APRIL to tumor cells as well as primary lymphoid cells.

물리적 형태

Lyophilized from PBS.

재구성

Reconstitute with 100 μL deionized water.

기타 정보

The extracellular domain of mouse APRIL (aa 88-232) is fused at the N-terminus to mouse ACRP30headless (aa 18-110) and a FLAG^®-tag.

법적 정보

FLAG is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable