추천 제품
생물학적 소스
human
재조합
expressed in E. coli
태그
GST tagged
분석
≥95% (SDS-PAGE)
양식
lyophilized
분자량
~52 kDa
포장
pkg of 100 μg
저장 조건
avoid repeated freeze/thaw cycles
기술
activity assay: suitable
색상
white
UniProt 수납 번호
배송 상태
wet ice
저장 온도
−20°C
유전자 정보
human ... ANXA5(308)
일반 설명
Annexin V is a member of the annexin family of calcium and membrane-binding proteins that have anticoagulatory and anti-inflammatory properties. The encoded protein is 320 amino acid long and is folded into four domains, each having five α-helices, forming a superhelical globular structure. The ANX5 gene is mapped to human chromosome 4q26-q28 and spans a length of 28kb containing 13 exons and 12 introns.
애플리케이션
Annexin V has been used to examine phosphorylation activity of ChaK1 (channel-kinase 1).
생화학적/생리학적 작용
Annexins are a family of water-soluble proteins that bind to membranes and phospholipids in a calcium-dependent manner. They participate in several cellular functions, such as membrane fusion and cytoskeletal interaction. Annexin V is a potent anticoagulant and serves as a voltage-gated calcium channel when bound to membrane in vitro. It is found to inhibit phospholipase A2 and protein kinase C.
물리적 형태
Lyophilized from PBS, pH 7.4.
재구성
Reconstitute with 100 μL deionized water.
기타 정보
Recombinant human annexin V fused to a GST-tag.
Storage Class Code
10 - Combustible liquids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
Marielle E Yohe et al.
Science translational medicine, 10(448) (2018-07-06)
The RAS isoforms are frequently mutated in many types of human cancers, including PAX3/PAX7 fusion-negative rhabdomyosarcoma. Pediatric RMS arises from skeletal muscle progenitor cells that have failed to differentiate normally. The role of mutant RAS in this differentiation blockade is
Xuerui Zhang et al.
Oncotarget, 8(26), 42602-42612 (2017-04-14)
Annexin V, a protein with high affinity to phosphatidylserine (PS) in a calcium dependent manner, has been widely used to probe apoptosis. Annexin V in inhibiting engulfment of apoptotic cells by macrophages had been reported to increase the immunogenicity of
Jesse D Gelles et al.
Cell death & disease, 7(12), e2493-e2493 (2016-12-03)
Quantitative and kinetic analyses of apoptotic cell death are integral components of exploring cell biology, measuring cellular stress responses, and performing high-throughput genomic/RNAi/drug screens. Here, we present a detailed method that integrates robust kinetic real-time high-content imaging with Annexin V
Zhiqiang Wei et al.
Chinese medicine, 15, 12-12 (2020-02-07)
Osteoarthritis (OA) is a metabolic disorder and able to be relieved by traditional Chinese medicines. However, the effect of Ligusticum wallichii on OA is unknown. Cytokine IL-1β and L. wallichii extracts were used to stimulate the primary mouse chondrocytes. MTT
Phosphorylation of annexin I by TRPM7 channel-kinase.
Dorovkov MV
The Journal of Biological Chemistry, 279, 50643-50646 (2004)
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