SRP8001

Calreticulin human

recombinant, expressed in E. coli, His tagged, >90% (SDS-PAGE)

• 동의어(들): CRP55, Calregulin, ERp60, Endoplasmic reticulum resident protein 60, grp60
• UNSPSC 코드: 12352200
• NACRES: NA.32

속성

• 생물학적 소스: human
• 재조합: expressed in E. coli
• 태그: His tagged
• 분석: >90% (SDS-PAGE)
• 형태: liquid
• 분자량: ~55 kDa by SDS-PAGE
• 포장: pkg of 10 μg
• 저장 조건: avoid repeated freeze/thaw cycles
• 기술: calcium flux assay: suitable
• 불순물: <1 EU/μg endotoxin, tested
• UniProt 수납 번호: P27797
• 배송 상태: wet ice
• 저장 온도: −20°C
• 유전자 정보: human ... CALR(811)

설명

일반 설명

Calreticulin (CALR) is expressed in the endoplasmic reticulum. The gene encoding it is localized on human chromosome 19p13.13.

애플리케이션

Human calreticulin has been used in a study to determine the effects of uncoupling protein 4 (UCP4) on the expression of proteins in the store-operated Ca²⁺ entry pathway.

생화학적/생리학적 작용

Calreticulin is involved in regulation of intracellular Ca²⁺ homoeostasis and ER Ca²⁺ capacity. It constitutes together with calnexin and ERp57 the ′calreticulin/calnexin cycle′ that is responsible for folding and quality control of newly synthesized glycoproteins. Calreticulin has been implicated to play a role in many biological systems, including functions inside and outside the ER, indicating that the protein is a multi-process molecule. Recently, Calreticulin was shown to enhance the merger of macrophages and tumor cells, increasing phagocytosis.

물리적 형태

Solution in 55 mM TRIS-HCl, pH 8.2, containing 150 mM NaCl.

기타 정보

Human calreticulin (aa18-417) is fused at the C-terminus to a His-tag.

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable