SRP6518

Plasminogen from human plasma

≥95% (SDS-PAGE)

• 동의어(들): PLG
• UNSPSC 코드: 12352202
• NACRES: NA.32

속성

• 생물학적 소스: human
• 분석: ≥95% (SDS-PAGE)
• 양식: lyophilized
• 분자량: 90.0 – 92.0 kDa
• 포장: pkg of 1 mg
• UniProt 수납 번호: P00747
• 배송 상태: wet ice
• 저장 온도: −20°C
• 유전자 정보: human ... PLG(5340)

설명

일반 설명

Plasminogen is the inactive precursor of plasmin. Plasminogen is activated by the action of either tissue plasminogen activator (tPA), which primarily activates the fibrinolytic (thrombolytic) activity of plasmin, or urokinase plasminogen activator (uPA), which is associated with extracellular matrix remodeling and cell migration.
Plasminogen is encoded by the gene mapped to human chromosome 6q26–27. The encoded protein is characterized with a leader, kringle and protease domains.

생화학적/생리학적 작용

Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. It cleaves fibrin/fibrinogen and blood coagulation factors V/Va and VIII/VIIIa. It activates matrix metalloproteinases by cleaving the inactive proenzymes. Plasmin is also involved in the activation of some growth factors, such as vascular endothelial growth factor (VEGF) and transforming growth factor β (TGF-β).

물리적 형태

Lyophilized from 20 mM Tris-HCl, pH 7.5, with 2 mM EDTA.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable