추천 제품
product name
Relaxin-3 human, recombinant, expressed in E. coli, ≥98% (SDS-PAGE)
생물학적 소스
human
재조합
expressed in E. coli
분석
≥98% (SDS-PAGE)
형태
lyophilized powder
분자량
5.5 kDa
포장
pkg of 10 μg
pkg of 50 μg
불순물
<1 EU/μg endotoxin (LAL test)
UniProt 수납 번호
배송 상태
wet ice
저장 온도
−20°C
유전자 정보
human ... RLN3(117579)
일반 설명
RLN3 (relaxin-3) is a relaxin peptide, belonging to the insulin superfamily, with each member containing two peptide subunits linked by three disulfide bridges. This protein shows a restricted expression pattern in the brain, mainly in lateral periaqueductal gray, nucleus incertus, and central gray regions in the brainstem. This protein is highly conserved across a range of species from fish to mammals.
생화학적/생리학적 작용
RLN3 (relaxin-3) functions as a ligand for the leucine-rich repeat-containing G-protein-coupled receptor (LGR), LGR7. It also acts as a ligand for orphan receptor GPCR135, or SALPR (somatostatin- and angiotensin-like peptide receptor). RLN3 acts on LGR7 resulting in stimulation of adenylate cycle; RLN3 acts on GPCR135 to prevent activation of adenylate cyclase. The RLN3–GPCR135 signaling pathway, functions alongside GABA neurotransmitter in specific brain areas, and has regulatory effects on putative GABA neuronal networks. It also interacts with pathways containing CRF (corticotrophin releasing hormone)-like peptides and their receptors. CRF-like peptides and their receptors are implicated in stress-induced autonomic and behavioral changes. RLN3–GPCR135 system is overall involved in arousal, learning and memory, stress, and locomotor activity.
물리적 형태
Sterile filtered through a 0.2 micron filter. Lyophilized with no additives.
재구성
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Relaxin-3 in GABA projection neurons of nucleus incertus suggests widespread influence on forebrain circuits via G-protein-coupled receptor-135 in the rat.
Neuroscience, 144(1), 165-190 (2007)
Central relaxin-3 administration causes hyperphagia in male Wistar rats.
Endocrinology, 146(8), 3295-3300 (2005)
Identification of relaxin-3/INSL7 as a ligand for GPCR142.
The Journal of Biological Chemistry, 278(50), 50765-50770 (2003)
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