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Merck
모든 사진(2)

Key Documents

SRP6155

Sigma-Aldrich

BMP-2 human

recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)

동의어(들):

BMP-2A, Bone morphogenetic protein 2, Bone morphogenetic protein 2A

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About This Item

UNSPSC 코드:
12352202
NACRES:
NA.32

생물학적 소스

human

재조합

expressed in HEK 293 cells

분석

≥95% (SDS-PAGE)

형태

lyophilized

효능

20-100 ng/mL ED50

분자량

30-38 kDa (homodimer, glycosylated)

포장

pkg of 10 μg

기술

cell culture | mammalian: suitable

NCBI 수납 번호

배송 상태

dry ice

저장 온도

−70°C

유전자 정보

human ... BMP2(650)

일반 설명

BMP2 (bone morphogenetic protein 2) belongs to the transforming growth factor-β (TGFβ) superfamily. BMP-2 is expressed in a variety of tissues such as lung, spleen, brain, liver, prostate ovary, and small intestine. BioVision′s BMP-2 is produced in a serum-free, chemically defined media. Production in human 293 cells offers authentic glycosylation, contributing to stability in cell growth media and other applications.BMP2 is a candidate gene for the autosomal dominant disease of fibrodysplasia (myositis) ossificans progressiva.

애플리케이션

BMP-2 human has been used to study the biological role of it on adult renal progenitor cells under in vitro and in vivo conditions.

생화학적/생리학적 작용

BMPs (bone morphogenetic proteins) promote and regulate bone development, growth, remodeling and repair, in both prenatal development and postnatal growth of eye, heart, kidney, skin, and other tissues. During bone repair, BMP-2 controls the expression of Runt-related transcription factor 2 (Runx2) and Osterix (Osx), thereby enhancing migration, proliferation and osteogenic differentiation of mesenchymal stem cells. In addition to its osteogenic activity, BMP-2 also plays an important role in cardiac morphogenesis.

물리적 형태

Lyophilized from a solution of 50 mM sodium acetate, pH 4.5, with 50 mM NaCl.

제조 메모

Centrifuge the vial prior to opening.

재구성

Reconstitute in sterile PBS containing 0.1% endotoxin-free, recombinant human serum albumin.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


시험 성적서(COA)

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문서 라이브러리 방문

Vera Hintze et al.
Biomacromolecules, 15(8), 3083-3092 (2014-07-17)
Sulfated glycosaminoglycans (GAGs) can direct cellular processes by interacting with proteins of the extracellular matrix (ECM). In this study we characterize the interaction profiles of chemically sulfated hyaluronan (HA) and chondroitin sulfate (CS) derivatives with bone morphogenetic protein-2 (BMP-2) and
Rick Visser et al.
Tissue engineering. Part A, 20(1-2), 34-44 (2013-07-19)
Osteogenesis is a complex, multifactorial process in which many different signals interact. The bone morphogenetic proteins (BMPs) are the most potent inducers of osteoblastic differentiation, although very high doses of BMPs in combination with collagen type I formulations have to
Ivo Dumic-Cule et al.
International orthopaedics, 38(9), 1979-1985 (2014-07-18)
Bone morphogenetic protein (BMP)-2 and -7 are used in patients with long-bone fractures, nonunions and spinal fusions. It is unknown whether their potential systemic bioavailability following local bone administration might affect skeletal metabolism. To answer this question, we examined effects
BMP-2 induces a profibrotic phenotype in adult renal progenitor cells through Nox4 activation.
Simone S, et al.
American Journal of Physiology: Renal Physiology, 303, F23-F34 (2012)
N M Shah et al.
Cell, 85(3), 331-343 (1996-05-03)
How growth factors influence the fate of multipotent progenitor cells is not well understood. Most hematopoietic growth factors act selectively as survival factors, rather than instructively as lineage determination signals. In the neural crest, neuregulin instructively promotes gliogenesis, but how

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