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Merck
모든 사진(1)

Key Documents

SRP6003

Sigma-Aldrich

Procalcitonin human

recombinant, expressed in E. coli, ≥97% (SDS-PAGE), ≥97% (HPLC)

동의어(들):

CALC1, CALCA, CGRP, Calcitonin

로그인조직 및 계약 가격 보기


About This Item

CAS Number:
UNSPSC 코드:
51111800
NACRES:
NA.32

생물학적 소스

human

재조합

expressed in E. coli

분석

≥97% (HPLC)
≥97% (SDS-PAGE)

형태

lyophilized

효능

80 ng/mL

분자량

12.796 kDa

포장

pkg of 10 μg

기술

cell culture | mammalian: suitable

불순물

Endotoxin, tested

NCBI 수납 번호

배송 상태

wet ice

저장 온도

−20°C

유전자 정보

human ... N/A(796)

일반 설명

The gene CALC1 (calcitonin 1) is mapped to human chromosome 11. CALC1 encodes for preprocalcitonin. Preprocalcitonin is cleaved by endopeptidase at the amino-terminal to produce procalcitonin. Procalcitonin works as a peptide hormone and is mainly produced by the C cells of the thyroid and certain endocrine cells of the lung. Under normal expression conditions, procalcitonin is immediately cleaved into three specific fragments, an N terminal residue, calcitonin and katacalcin. Recombinant human procalcitonin produced in Escherichia coli is a single, non-glycosylated, polypeptide chain containing 116 amino acids with a molecular weight of 12,796 Daltons.

애플리케이션

Procalcitonin human has been used in in vitro vascular permeability assay.

생화학적/생리학적 작용

Procalcitonin is a prohormone of calcitonin. Levels of unprocessed procalcitonin rise significantly after bacterial infection, trauma or shock. Procalcitonin is also associated with systemic complications in humans suffering from acute pancreatitis.

물리적 형태

Lyophilized from a 10 mM sodium phosphate buffer, pH 7.5.

재구성

Centrifuge the vial prior to opening. Reconstitute in sterile H?O to a concentration of 0.1 mg/ml.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

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문서 라이브러리 방문

Nana-Maria Wagner et al.
Anesthesia and analgesia, 124(3), 836-845 (2016-09-23)
Procalcitonin is used as a diagnostic tool for the identification and risk stratification of septic patients. Procalcitonin plasma concentrations tightly correlate with the severity of the ongoing inflammatory reaction and can rise up to 10,000-fold. Impairment of endothelial cell function
Physiology and genetics of procalcitonin.
Maruna P
Physiological Research, 49, S57-S61 (2000)
The potential role of procalcitonin and interleukin 8 in the prediction of infected necrosis in acute pancreatitis.
Rau B
Gut, 41, 832-832 (1997)
Procalcitonin as an acute phase marker.
Annals of Clinical Biochemistry, 38, 483-493 (2001)
High serum procalcitonin concentrations in patients with sepsis and infection.
Lancet, 341, 515-518 (1993)

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