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모든 사진(2)

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SRP5041

Sigma-Aldrich

JAK3 (781-end), active, GST tagged human

PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

동의어(들):

JAK-3, JAK3_HUMAN, JAKL, L-JAK, LJAK

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모든 사진(2)

About This Item

UNSPSC 코드:
12352200
NACRES:
NA.32

재조합

expressed in baculovirus infected Sf9 cells

제품 라인

PRECISIO® Kinase

분석

≥70% (SDS-PAGE)

형태

buffered aqueous glycerol solution

특이 활성도

77-104 nmol/min·mg

분자량

~64 kDa

NCBI 수납 번호

NM_000215

배송 상태

dry ice

저장 온도

−70°C

유전자 정보

human ... JAK3(3718)

일반 설명

JAK3 is a member of the JAK family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. Low levels of JAK3 expression is detected in immature hematopoietic cells, which dramatically increases during terminal differentiation of these cells suggesting a role of JAK3 in the differentiation of hematopoietic cells. Mutations in JAK3 are associated with autosomal SCID (severe combined immunodeficiency disease). Mice lacking JAK3 show a severe block in B-cell development at the pre-B stage in bone marrow suggesting that JAK3 is critical for the progression of B-cell development in the bone marrow.

물리적 형태

Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

제조 메모

after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles

법적 정보

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

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문서 라이브러리 방문

S M Russell et al.
Science (New York, N.Y.), 270(5237), 797-800 (1995-11-03)
Males with X-linked severe combined immunodeficiency (XSCID) have defects in the common cytokine receptor gamma chain (gamma c) gene that encodes a shared, essential component of the receptors of interleukin-2 (IL-2), IL-4, IL-7, IL-9, and IL-15. The Janus family tyrosine
D C Thomis et al.
Science (New York, N.Y.), 270(5237), 794-797 (1995-11-03)
Biochemical studies of signaling mediated by many cytokine and growth factor receptors have implicated members of the Jak family of tyrosine kinases in these pathways. Specifically, Jak3 has been shown to be associated with the interleukin-2 (IL-2) receptor gamma chain

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