SRP5020

DDR1 (444-end), active, GST tagged human

PRECISIO^® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

• 동의어(들): CAK, CD167, DDR, EDDR1, MCK10, NEP, NTRK4, PTK3, PTK3A, RTK6, TRKE
• UNSPSC 코드: 12352200
• NACRES: NA.32

속성

• 재조합: expressed in baculovirus infected Sf9 cells
• 제품 라인: PRECISIO^® Kinase
• 분석: ≥70% (SDS-PAGE)
• 형태: buffered aqueous glycerol solution
• 특이 활성도: 4.25-5.75 nmol/min·mg
• 분자량: ~77 kDa
• NCBI 수납 번호: NM_001954
• 배송 상태: dry ice
• 저장 온도: −70°C
• 유전자 정보: human ... DDR1(780)

설명

일반 설명

DDR1 is a member of the subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in its extracellular domain. DDR1 is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. Expression of DDR1 is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain and DDR1 is over-expressed in fast-growing invasive tumors of the breast, ovary, esophagus, brain and lung. Collagen type I mediated stimulation of DDR1 leads to activation of matrix metalloproteinase 2 and 9 as well as increased cell invasion.

물리적 형태

Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

제조 메모

after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles

법적 정보

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable