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Merck
모든 사진(1)

주요 문서

SRP4908

Sigma-Aldrich

Visfatin

recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC)

동의어(들):

Nicotinamide phosphoribosyltransferase, Pre-B-cell colony-enhancing factor 1 homolog

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About This Item

UNSPSC 코드:
12352200

생물학적 소스

mouse

재조합

expressed in E. coli

분석

≥95% (HPLC)
≥95% (SDS-PAGE)

형태

lyophilized

분자량

~55.0 kDa

포장

pkg of 10 μg

저장 조건

avoid repeated freeze/thaw cycles

불순물

endotoxin, tested

NCBI 수납 번호

배송 상태

wet ice

저장 온도

−20°C

유전자 정보

mouse ... Nampt(59027)

일반 설명

Visfatin is also called pre-B cell colony enhancing factor, nicotinamide phosphoribosyltransferase, pre-B-cell colony-enhancing factor 1 homolog, NAmPRTase, Nampt and PBEF. Visfatin is an adipocytokine produced by visceral fat.

생화학적/생리학적 작용

Visfatin has a role in mammalian nicotinamide adenine dinucleotide (NAD+) biosynthesis. Studies have shown that mice deficient in visfatin in the forebrain excitatory neurons show hyperactivity, diminished anxiety-like behaviors and impaired learning and memory. It has also been shown that visfatin stimulates glucose uptake and adenosine monophosphate-activated protein kinase (AMPK) phosphorylation in mouse C2C12 skeletal muscle cells.

물리적 형태

Lyophilized without any additives.

재구성

Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in PBS to the concentration of 0.1-1 mg/mL.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


시험 성적서(COA)

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문서 라이브러리 방문

The evolutionary portrait of metazoan NAD salvage.
Carneiro J
PLoS ONE, 8(5), e64674-e64674 (2013)
Visfatin, a novel adipokine, stimulates glucose uptake through the Ca2 +-dependent AMPK-p38 MAPK pathway in C2C12 skeletal muscle cells.
Lee JO
Journal of Molecular Endocrinology, 54(3), 251-262 (2015)
Liana Roberts Stein et al.
Brain research bulletin, 119(Pt A), 41-51 (2015-10-21)
Nicotinamide adenine dinucleotide (NAD(+)) is an essential coenzyme/cosubstrate for many biological processes in cellular metabolism. The rate-limiting step in the major pathway of mammalian NAD(+) biosynthesis is mediated by nicotinamide phosphoribosyltransferase (Nampt). Previously, we showed that mice lacking Nampt in
Jiawen Yong et al.
Journal of cellular and molecular medicine, 25(20), 9710-9723 (2021-09-16)
Hypoxia-induced apoptosis of cementoblasts (OCCM-30) may be harmful to orthodontic treatment. Hypoxia-inducible factor 1-alpha (HIF-1α) mediates the biological effects during hypoxia. Little is known about the survival mechanism capable to counteract cementoblast apoptosis. We aimed to investigate the potential roles
Yuri L Boteon et al.
PloS one, 13(7), e0201419-e0201419 (2018-07-26)
Pharmacological defatting of rat hepatocytes and hepatoma cell lines suggests that the same method could be used to ameliorate macrovesicular steatosis in moderate to severely fatty livers. However there is no data assessing the effects of those drugs on primary

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