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Merck
모든 사진(1)

주요 문서

SRP3291

Sigma-Aldrich

NESFATIN-1 human

recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)

동의어(들):

none

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About This Item

UNSPSC 코드:
12352200
NACRES:
NA.77

생물학적 소스

human

재조합

expressed in E. coli

분석

≥98% (HPLC)
≥98% (SDS-PAGE)

형태

lyophilized

분자량

9.7 kDa

포장

pkg of 100 μg

불순물

<0.1 EU/μg endotoxin, tested

색상

white to off-white

UniProt 수납 번호

배송 상태

wet ice

저장 온도

−20°C

유전자 정보

human ... NUCB2(4925)

일반 설명

Originally identified as a hypothalamic neuropeptide, Nesfatin-1 is also expressed in other areas of the brain, and in pancreatic islets β-cells, gastric endocrine cells and adipocytes.  Nesfatin-1 suppresses food intake and can regulate energy metabolism in a Leptin independent manner.

생화학적/생리학적 작용

Nesfatin-1 is a metabolic polypeptide encoded in the N-terminal region of the precursor protein, Nucleobindin2 (NUCB2). Recombinant human Nesfatin-1 is a 9.7 kDa protein containing 82 amino acid residues.

물리적 형태

Lyophilized from 10 mM Sodium Phosphate, pH 6.5.

재구성

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


시험 성적서(COA)

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문서 라이브러리 방문

Andreas Stengel et al.
Regulatory peptides, 163(1-3), 18-23 (2010-06-29)
Nesfatin-1 is an 82 amino acid peptide recently discovered in the brain which is derived from nucleobindin2 (NUCB2), a protein that is highly conserved across mammalian species. Nesfatin-1 has received much attention over the past two years due to its
Yusaku Mori et al.
Endocrine connections, 8(5), 536-546 (2019-04-03)
Nesfatin-1 is a novel anorexic peptide hormone that also exerts cardiovascular protective effects in rodent models. However, nesfatin-1 treatment at high doses also exerts vasopressor effects, which potentially limits its therapeutic application. Here, we evaluated the vasoprotective and vasopressor effects

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