추천 제품
생물학적 소스
mouse
재조합
expressed in E. coli
분석
≥98% (HPLC)
≥98% (SDS-PAGE)
형태
lyophilized
효능
≤10 ng/mL ED50
분자량
17.5 kDa
포장
pkg of 10 μg
기술
cell culture | mammalian: suitable
불순물
<0.1 EU/μg endotoxin, tested
색상
white to off-white
UniProt 수납 번호
배송 상태
wet ice
저장 온도
−20°C
유전자 정보
mouse ... IL33(77125)
일반 설명
IL-33 (interleukin 33) is an IL-1 family member, and shows high expression levels in endothelial cells and epithelium, such as keratinocytes, that are in direct contact with the environment.
Recombinant murine IL-33 is a 17.5kDa protein containing 158 amino acid residues.
Recombinant murine IL-33 is a 17.5kDa protein containing 158 amino acid residues.
생화학적/생리학적 작용
IL-33 (interleukin 33) functions as an extracellular cytokine, and also translocates to the nucleus where it inhibits gene expression. It acts as a ligand for ST2/ IL-1 receptor-like 1 (growth STimulation expressed gene 2), and ST2 is expressed on cells such as CD34+ hematopoietic progenitor cells, eosinophils, basophils, T-helper 2 cell (Th2), and dendritic, NK (natural killer), endothelial and mast cells. Polymorphisms in this gene as well as its receptor are linked with atopic dermatitis, allergies and asthma. In Orientia tsutsugamushi-infected mice, IL-33 is involved in endothelial cell damage and renal injury.
Recombinant murine IL-33 is a 17.5kDa protein containing 158 amino acid residues.
Recombinant murine IL-33 is a 17.5kDa protein containing 158 amino acid residues.
서열
SIQGTSLLTQ SPASLSTYND QSVSFVLENG CYVINVDDSG KDQEQDQVLL RYYESPCPAS QSGDGVDGKK LMVNMSPIKD TDIWLHANDK DYSVELQRGD VSPPEQAFFV LHKKSSDFVS FECKNLPGTY IGVKDNQLAL VEEKDESCNN IMFKLSKI
물리적 형태
Lyophilized from 10 mM Sodium Phosphate, pH 8.0 + 750mM NaCl.
재구성
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.
Storage Class Code
11 - Combustible Solids
WGK
WGK 2
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
IL-33-Dependent Endothelial Activation Contributes to Apoptosis and Renal Injury in Orientia tsutsugamushi-Infected Mice.
Shelite TR et al
PLoS Neglected Tropical Diseases, 10(3), e0004467-e0004467 (2016)
Targeting the IL-1 family members in skin inflammation.
Jensen LE
Current Opinion in Investigational Drugs, 11(11), 1211-1220 (2010)
Ying Lei et al.
PloS one, 10(7), e0133774-e0133774 (2015-07-28)
In several clinical and experimental studies IL-33 and its receptor have been found to play important roles in the development of asthma and allergic airway inflammation. We evaluated the effects of vaccination against IL-33 in a mouse model of airway
Elizabeth A Oczypok et al.
The Journal of allergy and clinical immunology, 136(3), 747-756 (2015-05-02)
Single nucleotide polymorphisms in the human gene for the receptor for advanced glycation end-products (RAGE) are associated with an increased incidence of asthma. RAGE is highly expressed in the lung and has been reported to play a vital role in
Amy K Y Fu et al.
Proceedings of the National Academy of Sciences of the United States of America, 113(19), E2705-E2713 (2016-04-20)
Alzheimer's disease (AD) is a devastating condition with no known effective treatment. AD is characterized by memory loss as well as impaired locomotor ability, reasoning, and judgment. Emerging evidence suggests that the innate immune response plays a major role in
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