SRP2147

CAR-LBD (101-348), GST tagged human

recombinant, expressed in E. coli, ≥70% (SDS-PAGE)

• 동의어(들): CAR, CAR1, MB67, MGC150433, MGC97144, MGC97209
• UNSPSC 코드: 12352202
• NACRES: NA.26

속성

• 생물학적 소스: human
• 재조합: expressed in E. coli
• 분석: ≥70% (SDS-PAGE)
• 형태: frozen liquid
• 분자량: ~55.3 kDa
• 포장: pkg of 10 μg
• 저장 조건: avoid repeated freeze/thaw cycles
• 농도: 100 μg/mL
• 색상: clear; colorless
• NCBI 수납 번호: NM_005122
• UniProt 수납 번호: Q14994
• 배송 상태: dry ice
• 저장 온도: −70°C
• 유전자 정보: human ... NR1I3(9970)

설명

일반 설명

The gene encoding this protein is localized on human chromosome 1q23.3.

생화학적/생리학적 작용

It forms a complex with phosphatase 2A, heat shock protein 90 (Hsp90) and cytosolic CAR retention protein in the cytoplasm. On activation, it translocates to the nucleus and modulates the expression of genes associated with drug metabolism. The protein regulates transforming growth factor-β (TGF-β) signaling.

The constitutive androstane receptor (CAR) was identified as a member of the orphan nuclear hormone receptor family in 1994. Although constitutively active, it can be further activated by ′phenobarbitol-like′ compounds, the most potent being the synthetic compound TCPOBOP. Upon activation, CAR regulates the xenobiotic drug metabolizing enzymes, cytochrome P450s. There are several overlapping functions between the nuclear receptors PXR and CAR. Recently, CAR, as well as PXR, have been shown to place a role in bile acid clearance and cholestatic liver injury.

물리적 형태

Clear and colorless frozen liquid solution

제조 메모

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable