SRP2061

RAR γ-ligand binding domain (150-417) human

recombinant, expressed in E. coli, ≥80% (SDS-PAGE)

• 동의어(들): NR1B3, RARC
• UNSPSC 코드: 12352202
• NACRES: NA.26

속성

• 생물학적 소스: human
• 재조합: expressed in E. coli
• 분석: ≥80% (SDS-PAGE)
• 형태: frozen liquid
• 분자량: ~29.5 kDa
• 포장: pkg of 10 μg
• 저장 조건: avoid repeated freeze/thaw cycles
• 농도: 700 μg/mL
• 색상: clear colorless
• NCBI 수납 번호: NM_000966
• UniProt 수납 번호: P13631
• 배송 상태: dry ice
• 저장 온도: −70°C
• 유전자 정보: human ... RARG(5916)

설명

생화학적/생리학적 작용

Retinoic acid receptors are important in the regulation of growth and differentiation of epithelial tissues, embryonic and central nervous system development and hematopoiesis. Retinoids mediate their effect by two classes of nuclear receptor proteins, the retinoic acid receptors (RARs) and the retinoid X receptors (RXRs), that each consist of three isotypes ( α, β, and γ) encoded in separate genes. Upon dimerization with RXR, RARs can bind to specific enhancer sequences in the DNA, so-called retinoic acid response elements (RAREs), resulting in transcriptional activation of target genes in the presence of ligand. The RAR-gamma in the adult is found almost exclusively in the skin. Retinoids affect epidermal cell growth and differentiation as well as sebaceous gland activity and exhibit immunomodulatory and anti-inflammatory properties. Current retinoid research targets the development of receptor-selective retinoids for tailoring and/or improving their therapeutic profile.

물리적 형태

Clear and colorless frozen liquid solution

제조 메모

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable