재조합
expressed in baculovirus infected Sf9 cells
분석
70-95% (SDS-PAGE)
형태
frozen liquid
특이 활성도
35-55 nmol/min·mg (radiometric)
분자량
~64 kDa (Cyclin Y)
~76 kDa (PCTK3)
농도
0.1 μg/μL
수납 번호(accession number)
BC011526
NM_145012
배송 상태
dry ice
저장 온도
−70°C
유전자 정보
human ... CCNY(219771) , CDK18(5129)
애플리케이션
Useful for kinase assay and Western blot.
생화학적/생리학적 작용
Full-length recombinant human PCTK3 (CDK18) and Cyclin Y (2-end) were co-expressed by Baculovirus in Sf9 insect cells using N-terminal GST tags. PCTK3 or PCTAIRE protein kinase 3 is a member of the cdc2/cdkx subfamily of the ser/thr family of protein kinases. PCTK3 is thought to play a role in terminally differentiated neurons and it contains an N-terminal extension relative to CDC2 (1). PCTK3 is expressed in a variety of human cell lines and tissues (2). Elevation in the protein levels of PCTAIRE 3 in the temporal cortex of Alzheimer′s disease relative to control brains, have been observed. It is proposed that PCTAIRE 3 is a paired helical filaments-associated kinase that modulates tau phosphorylation.
재구성
Formulated in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, with 25% glycerol.
저장 및 안정성
Store in aliquots at -70°C. Avoid freeze/thaw cycles.
법적 정보
PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
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