생물학적 소스
human
재조합
expressed in baculovirus infected Sf9 cells
분석
≥44% (SDS-PAGE)
양식
aqueous solution
분자량
65 kDa
포장
pkg of 50 μg
NCBI 수납 번호
UniProt 수납 번호
배송 상태
dry ice
저장 온도
−70°C
유전자 정보
human ... SESN1(27244)
일반 설명
Human Sestrin1, also known as p53-regulated protein PA26 (GenBank Accession No. NM_014454) full length, amino acids 2-551(end) with N-terminal FLAG-tag, MW=65 kDa, expressed in Sf9 insect cells via a Baculovirus expression system.
애플리케이션
Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Storage Class Code
10 - Combustible liquids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
시험 성적서(COA)
Lot/Batch Number
Broderick, G., et al.
The Pharmacogenomics Journal, 7, 407-419 (2006)
Andrei V Budanov et al.
Cell, 134(3), 451-460 (2008-08-12)
The tumor suppressor p53 is activated upon genotoxic and oxidative stress and in turn inhibits cell proliferation and growth through induction of specific target genes. Cell growth is positively regulated by mTOR, whose activity is inhibited by the TSC1:TSC2 complex.
Jun Hee Lee et al.
Science (New York, N.Y.), 327(5970), 1223-1228 (2010-03-06)
Sestrins are conserved proteins that accumulate in cells exposed to stress, potentiate adenosine monophosphate-activated protein kinase (AMPK), and inhibit activation of target of rapamycin (TOR). We show that the abundance of Drosophila sestrin (dSesn) is increased upon chronic TOR activation
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