SRP0310

HDAC6 H216A human

recombinant, expressed in baculovirus infected Sf9 cells, ≥75% (SDS-PAGE)

• 동의어(들): HD6, JM21, histone deacetylase 6
• UNSPSC 코드: 12352200
• NACRES: NA.32

속성

• 생물학적 소스: human
• 재조합: expressed in baculovirus infected Sf9 cells
• 분석: ≥75% (SDS-PAGE)
• 형태: aqueous solution
• 분자량: 161 kDa
• 포장: pkg of 50 μg
• 저장 조건: avoid repeated freeze/thaw cycles
• 농도: 0.65 mg/mL
• NCBI 수납 번호: NM_006044
• UniProt 수납 번호: Q9UBN7
• 배송 상태: dry ice
• 저장 온도: −70°C
• 유전자 정보: human ... HDAC6(10013)

설명

일반 설명

HDAC6 (histone deacetylase 6) belongs to the HDAC family of proteins. HDACs are responsible for deacetylation of nuclear histone and nonhistone proteins, including transcription factors. The mutation H216A results in catalytically inactive HDAC6.
Human HDAC6 with H216A mutation (GenBank Accession No. NM_006044), full length with N-terminal GST tag, MW= 161kDa, expressed in a Baculovirus expression system.

생화학적/생리학적 작용

HDAC6 (histone deacetylase 6) is involved in the control of microtubules, growth factor-mediated chemotaxis, stress response in presence of misfolded protein and tumor invasion. It also participates in EGF (epidermal growth factor)-mediated β-catenin nuclear presence and activation of c-myc. In mouse model, HDAC6 is implicated in oncogene-induced tumorigenesis. HDAC6 is the main deacetylase for α-tubulin and thus, is involved in cell motility. It is also involved in the formation of SGs (stress granules) and SG proteins. Mutations in the 3′-UTR of the HDAC6 gene suppresses hsa-miR-433-mediated post-transcriptional regulation. This results in overexpression of HDAC6, thereby causing X-linked chondrodysplasia.

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable