SRP0300

TGF-β1 Latent human

recombinant, expressed in FreeStyle^™ 293-F cells, ≥98% (SDS-PAGE)

• 동의어(들): LAP, TGFb1, TGFbeta1, latency-associated peptide, transforming growth factor beta-1
• UNSPSC 코드: 12352202
• NACRES: NA.32

속성

• 생물학적 소스: human
• 재조합: expressed in FreeStyle^™ 293-F cells
• 분석: ≥98% (SDS-PAGE)
• 형태: aqueous solution
• 분자량: 25 kDa
• 포장: pkg of 5 μg
• 제조업체/상표: Invitrogen
• 저장 조건: avoid repeated freeze/thaw cycles
• NCBI 수납 번호: NM_000660
• UniProt 수납 번호: Q14766
• 배송 상태: dry ice
• 저장 온도: −70°C
• 유전자 정보: human ... LTBP1(4052)

설명

일반 설명

Human TGFβ1 (GenBank Accession No. NM_000660), amino acids 30-390 (end) with Cys33Ser mutation and N-terminal His-tag, disulfide-linked homodimers of TGFβ1 LAP and mature TGFβ1, MW= ~75kDa and 25kDa, under non-reducing conditions.
LTBP1 (latent transforming growth factor β binding protein 1) belongs to the LTBP family of proteins. The protein has 18 epidermal growth factor (EGF)-like repeats and four LTBP-like repeats. The gene is mapped to human chromosome 2p22.3.

애플리케이션

Useful for cell culture and for the study of signaling and apoptotic pathways.

생화학적/생리학적 작용

LTBP1 (latent transforming growth factor β binding protein 1) is an extracellular matrix protein which also controls TGF-β (transforming growth factor β) bioavailability. LTBP1 is mainly responsible for the folding and secretion of TGF-β, thereby adding it to the extracellular matrix. It is a target of HTRA1 (high temperature requirement protein A1), a serine protease involved in cellular signaling.

물리적 형태

Lyophilized from a 0.2 μM filtered, aqueous solution.

재구성

Reconstitute in sterile PBS with 0.1% BSA. Stability: >6 months at –70°C (as a solid). Store reconstituted protein in aliquots at –80°C for up to 3 months. Avoid freeze/thaw cycles.

법적 정보

FreeStyle is a trademark of Invitrogen Corp.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable