SRP0107

HDAC-5 full length human

recombinant, expressed in baculovirus infected insect cells, ≥10% (SDS-PAGE)

• 동의어(들): HD5, Histone deacetylase 5, NY-CO-9
• UNSPSC 코드: 12352200
• NACRES: NA.32

속성

• 생물학적 소스: human
• 재조합: expressed in baculovirus infected insect cells
• 분석: ≥10% (SDS-PAGE)
• 양식: aqueous solution
• 효능: ≥1 units/mg
• 분자량: 150 kDa
• 포장: pkg of 5 μg
• 저장 조건: avoid repeated freeze/thaw cycles
• 농도: >0.02 mg/mL
• NCBI 수납 번호: NM_001015053
• UniProt 수납 번호: Q9UQL6
• 배송 상태: dry ice
• 저장 온도: −70°C
• 유전자 정보: human ... HDAC5(10014)

설명

일반 설명

Histone deacetylase 5 (HDAC5) belongs to the Hda1-like proteins class IIa HDAC family. It contains 17 phospho-acceptor residues and a classical deacetylase domain. The HDAC5 gene is mapped to human chromosome 17q21.

애플리케이션

HDAC-5 full-length human has been used in the adenosine diphosphate (ADP)-Glo assay and Γ-p³²-adenosine triphosphate (ATP) radioisotope assay with focal adhesion kinase (FAK) kinase.

생화학적/생리학적 작용

Histone deacetylase 5 (HDAC5) mediates synoviocyte activation, neural repair and regeneration. It regulates the assembly of the pericentric heterochromatin. Elevated expression of HDAC5 is implicated in high-risk medulloblastoma and breast cancer in very young women (BCVY).

단위 정의

One unit is defined as the amount of enzyme required to deacetylate 1 pmol of substrate/min at 37°C.

물리적 형태

Formulated in 25 mM Tris-HCl, pH 8.0, 138 mM NaCl, 0.05% Tween-20 and 10% glycerol.

제조 메모

Thaw on ice. Upon first thaw, briefly spin tube containing enzyme to recover full content of the tube. Aliquot enzyme into single use aliquots. Store remaining undiluted enzyme in aliquots at -70°C. Note: Enzyme is very sensitive to freeze/thaw cycles.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1