SML4019

Neuromedin U-23 (rat) trifluoroacetate

≥95% (HPLC)

• 동의어(들): L-Tyrosyl-L-lysyl-L-valyl-L-asparaginyl-L-α-glutamyl-L-tyrosyl-L-glutaminylglycyl-L-prolyl-L-valyl-L-alanyl-L-prolyl-L-serylglycylglycyl-L-phenylalanyl-L-phenylalanyl-L-leucyl-L-phenylalanyl-L-arginyl-L-prolyl-L-arginyl-L-aspartamide trifluoroacetate, Neuromedin U trifluoroacetate, Phe-Lys-Ala-Glu-Tyr-Gln-Ser-Pro-Ser-Val-Gly-Gln-Ser-Lys-Gly-Tyr-Phe-Leu-Phe-Arg-Pro-Arg-Asn-NH2 trifluoroacetate, Rat neuromedin U-23 trifluoroacetate, YKVNEYQGPVAPSGGFFLFRPRN-NH2 trifluoroacetate
• 실험식(Hill 표기법): C₁₂₄H₁₈₀N₃₄O₃₁
• Molecular Weight: 2642.97
• UNSPSC 코드: 12352200

속성

• Quality Level: 100
• 분석: ≥95% (HPLC)
• 형태: (Powder or Lyophilized powder or film)
• 저장 조건: desiccated
• 색상: white to off-white
• 저장 온도: -10 to -25°C
• SMILES string: O=C([C@H](CC1=CC=CC=C1)NC([C@H](CC(C)C)NC([C@@H](NC([C@@H](NC(CNC(CNC([C@H](CO)NC([C@H]2CCCN2C([C@@H](NC([C@H](C(C)C)NC(C3N(CCC3)C(CNC([C@@H](NC([C@H](CC4=CC=C(C=C4)O)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CCCCN)NC([C@@H](N)CC5=CC=C(C=C5)O)=O)=O)C(C)C)=O)

설명

생화학적/생리학적 작용

Endogenous agonist of neuromedin-U receptor 1 (NMUR1) and neuromedin-U receptor 2 (NMUR2)



Neuromedin U-23 (Neuromedin U), a neuropeptide, is endogenous agonist of neuromedin-U receptor 1 (EC50 = 0.17 nM) and neuromedin-U receptor 2 (EC50 = 1.4 nM) that regulates blood pressure, ion transport in the gut, mesenteric blood flow and adrenocortical function. Neuromedin U-23 decreases body weight and food intake and increases core body temperature in mice when administered at a dose of 36 µg/animal. It appears that neuromedin U regulates epithelial cell differentiation and barrier immunity through interaction with neuromedin-U receptor 1 present at small intestine eosinophils.

주의사항

Hygroscopic

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable