SML3643
EP2 antagonist C52
≥98% (HPLC)
동의어(들):
4-((9-Chloro-7-(5-fluoro-1H-indol-1-yl)-2,3-dihydrobenzo[f ]-[1,4]oxazepin-4(5H)-yl)methyl)pyridin-2(1H)-one, 4-[[9-Chloro-7-(5-fluoro-1H-indol-1-yl)-2,3-dihydro-1,4-benzoxazepin-4(5H)-yl]methyl]-2(1H)-pyridinone, Benzoxazepine 52, C52, Compound 52, EP2 antagonist compound 52
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모든 사진(1)
About This Item
실험식(Hill 표기법):
C23H19ClFN3O2
CAS Number:
Molecular Weight:
423.87
UNSPSC 코드:
12352200
NACRES:
NA.25
추천 제품
Quality Level
분석
≥98% (HPLC)
형태
powder
색상
white to beige
solubility
DMSO: 2 mg/mL, clear (Warmed)
저장 온도
2-8°C
SMILES string
O=C1C=C(CN2CC3=CC(N4C=CC5=C4C=CC(F)=C5)=CC(Cl)=C3OCC2)C=CN1
생화학적/생리학적 작용
Compound 52 (C52) is an orally active, brain-penetrant, highly potent and selective prostaglandin E2 (PGE2) receptor 2 (EP2) antagonist (h/r/m EP2 IC50 = 8/10/10 nM against PGE2 binding, IC50 = 5/3/4 nM against 10 nM PGE2-induced cellular cAMP) with ∼4000-fold selectivity over other EP receptors (hEP1/3/4 IC50 >30 μM against PGE2 binding; hCRTH2/DP/IP/TP IC50 >33 μM against LTD4-induced cellular Ca2+) and no CYP inhibitory potency. C52 reduces inflammatory neurodegeneration in a murine model of cerebral ischemia (10 mg/kg p.o. 4.5h & 24h post MCAO) and restores cognition in aged mice (10 mg/kg/d p.o.) by rejuvenating cellular bioenergetics in vivo.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Brian M Fox et al.
Journal of medicinal chemistry, 58(13), 5256-5273 (2015-06-11)
A high-throughput screen resulted in the discovery of benzoxazepine 1, an EP2 antagonist possessing low microsomal stability and potent CYP3A4 inhibition. Modular optimization of lead compound 1 resulted in the discovery of benzoxazepine 52, a molecule with single-digit nM binding
Paras S Minhas et al.
Nature, 590(7844), 122-128 (2021-01-22)
Ageing is characterized by the development of persistent pro-inflammatory responses that contribute to atherosclerosis, metabolic syndrome, cancer and frailty1-3. The ageing brain is also vulnerable to inflammation, as demonstrated by the high prevalence of age-associated cognitive decline and Alzheimer's disease4-6.
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