SML3492

Chromenone 1

≥98% (HPLC)

• 동의어(들): 2-(1H-1,2,4-Triazol-1-yl)-3-[4-(trifluoromethyl)phenyl]-4H-1-benzopyran-4-one
• 실험식(Hill 표기법): C₁₈H₁₀F₃N₃O₂
• CAS Number: 1639929-29-5
• Molecular Weight: 357.29
• UNSPSC 코드: 51111800
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 형태: powder
• 색상: white to beige
• solubility: DMSO: 2 mg/mL, clear
• 저장 온도: 2-8°C
• SMILES string: O=C1C(C2=CC=C(C=C2)C(F)(F)F)=C(OC3=CC=CC=C13)N4N=CN=C4

설명

생화학적/생리학적 작용

Chromenone 1 is a bone morphogenetic protein (BMP) signaling potentiator that exerts its effect via negative TGFβ feedback loops, independent of direct kinase inhibition. Chromenone 1 prevents cardiogenesis induction by 0.5 μM BMP inhibitor DMH1 (IC50 = 200 nM; mESC-Myh6-GFP) and efficiently stimulates BMP-dependent osteogenesis from C2C12 myoblasts (ALP activity induction EC50 = 340 nM; E100% and Emax = induction by 7.5 and 50 ng/mL BMP-4, respectively).

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable