SML3405

NVP-LDZ982

≥98% (HPLC)

• 동의어(들): LDZ-982, LDZ 982, LDZ982, Methyl 5-[1-(3-chlorophenyl)-5-(trifluoromethyl)-1H-pyrazol-4-yl]-3-(2,6-dichlorophenyl)isoxazole-4-carboxylate, NITD 982, NITD-982, NITD982
• 실험식(Hill 표기법): C₂₁H₁₁Cl₃F₃N₃O₃
• CAS Number: 1357266-65-9
• Molecular Weight: 516.68
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: , Light yellow to orange
• solubility: DMSO: 2 mg/mL, clear
• 저장 온도: 2-8°C

설명

생화학적/생리학적 작용

Dihydroorotate dehydrogenase (DHODH) inhibitor with broad-spectrum antiviral activity against Dengue, HCV, HIV, Influenza, RSV, and Yellow fever.

NVP-LDZ982 (NITD-982) is a dihydroorotate dehydrogenase (DHODH) inhibitor (Kd = 27 nM) with broad-spectrum antiviral activity by targeting host cell de novo pyrimidine biosynthesis pathway. NITD-982 inhibits various viral replications in cultues, including Dengue (DENV EC50 = 5-2.6 nM; A549), hepatitis C virus (HCV EC50 = 7-12.6 nM; Huh-7), HIV (MDR769 EC50 = 0.97 nM; PBMC), Influenza (EC50 = 32 nM/H1N1, 117 nM/B, 217 nM/H1N3; MDCK), respiratory syncytial virus (RSV EC50 = 7-9 nM; Hep-2), and Yellow fever (strain 17D EC50 = 8.2 nM; A549).

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable