추천 제품
Quality Level
분석
≥98% (HPLC)
양식
(Powder or Lyophilized powder or film or oil)
색상
colorless to brown-yellow
저장 온도
2-8°C
SMILES string
CCCC1=NC2=CC=NN2C(N[C@H]3C[C@@H](CC3)N)=C1
생화학적/생리학적 작용
KI-ARv-03 is a cell penetrant, potent and selective inhibitor of CDK9 that that reduces AR-driven transcription and proliferation in prostate cancer cells. KI-ARv-03 modulates AR and AR-V7-dependent transcription in 22Rv1 cells. It exhibits potent anti-tumor activity in castration-resistant prostate cancer (CRPC) models.
Orally available, potent, ultraselective CDK9 inhibitor that exhibits potent anti-tumor activity in castration-resistant prostate cancer (CRPC) models
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
Modulating Androgen Receptor-Driven Transcription in Prostate Cancer with Selective CDK9 Inhibitors.
André Richters et al.
Cell chemical biology, 28(2), 134-147 (2020-10-22)
Castration-resistant prostate cancers (CRPCs) lose sensitivity to androgen-deprivation therapies but frequently remain dependent on oncogenic transcription driven by the androgen receptor (AR) and its splice variants. To discover modulators of AR-variant activity, we used a lysate-based small-molecule microarray assay and
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