SML3218

Odevixibat

≥98% (HPLC)

• 동의어(들): (2S)-2-[(2R)-2-(2-{[3,3-Dibutyl-7-(methylsulfanyl)-1,1-dioxo-5-phenyl-2,3,4,5-tetrahydro-1H-1λ6,2,5-benzothiadiazepin-8-yl]oxy}acetamido)-2-(4-hydroxyphenyl)acetamido]butanoic acid, (2S)-2-[[(2R)-2-[[2-[[3,3-Dibutyl-2,3,4,5-tetrahydro-7-(methylthio)-1,1-dioxido-5-phenyl-1,2,5-benzothiadiazepin-8-yl]oxy]acetyl]amino]-2-(4-hydroxyphenyl)acetyl]amino]butanoic acid, A 4250, A-4250, A4250, AZD 8294, AZD-8294, AZD8294
• 실험식(Hill 표기법): C₃₇H₄₈N₄O₈S₂
• CAS Number: 501692-44-0
• Molecular Weight: 740.93
• MDL number: MFCD32710220
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: white to beige
• solubility: DMSO: 2 mg/mL, clear
• 저장 온도: −20°C
• SMILES string: O=S1(C2=CC(OCC(N[C@H](C3=CC=C(C=C3)O)C(N[C@@H](CC)C(O)=O)=O)=O)=C(SC)C=C2N(C4=CC=CC=C4)CC(CCCC)(N1)CCCC)=O
• InChI: 1S/C37H48N4O8S2/c1-5-8-19-37(20-9-6-2)24-41(26-13-11-10-12-14-26)29-21-31(50-4)30(22-32(29)51(47,48)40-37)49-23-33(43)39-34(25-15-17-27(42)18-16-25)35(44)38-28(7-3)36(45)46/h10-18,21-22,28,34,40,42H,5-9,19-20,23-24H2,1-4H3,(H,38,44)(H,39,43)(H,45,46)/t28-

설명

생화학적/생리학적 작용

Odevixibat is an orally active, potent and selective ileal bile acid transporter (IBAT; ASBT; SLC10A2) inhibitor that improves cholestatic liver and bile duct injury in a mouse model of sclerosing cholangitis (0.01% w/w in diet).

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable