SML3162
A-1155463
≥98% (HPLC)
동의어(들):
2-[8-[(2-Benzothiazolylamino)carbonyl]-3,4-dihydro-2(1H)-isoquinolinyl]-5-[3-[4-[3-(dimethylamino)-1-propyn-1-yl]-2-fluorophenoxy]propyl]-4-thiazolecarboxylic acid, A 1155463
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모든 사진(1)
About This Item
실험식(Hill 표기법):
C35H32FN5O4S2
CAS Number:
Molecular Weight:
669.79
MDL number:
UNSPSC 코드:
12352200
NACRES:
NA.77
추천 제품
Quality Level
분석
≥98% (HPLC)
양식
powder
색상
white to beige
solubility
DMSO: 2 mg/mL, clear
저장 온도
−20°C
SMILES string
O=C(C1=C(CN(C2=NC(C(O)=O)=C(CCCOC3=CC=C(C#CCN(C)C)C=C3F)S2)CC4)C4=CC=C1)NC5=NC6=C(S5)C=CC=C6
InChI
1S/C35H32FN5O4S2/c1-40(2)17-6-8-22-14-15-28(26(36)20-22)45-19-7-13-30-31(33(43)44)38-35(47-30)41-18-16-23-9-5-10-24(25(23)21-41)32(42)39-34-37-27-11-3-4-12-29(27)46-34/h3-5,9-12,14-15,20H,7,13,16-19,21H2,1-2H3,(H,43,44)(H,37,39,42)
생화학적/생리학적 작용
A-1155643 is a highly potent and highly selective BCLXL inhibitor that inhibits H146 small cell lung cancer xenograft tumor growth in mice.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
G Brent Dawe et al.
Nature communications, 10(1), 2746-2746 (2019-06-23)
Nicotinic acetylcholine receptors (nAChRs) mediate and modulate synaptic transmission throughout the brain, and contribute to learning, memory, and behavior. Dysregulation of α7-type nAChRs in neuropsychiatric as well as immunological and oncological diseases makes them attractive targets for pharmaceutical development. Recently
Zhi-Fu Tao et al.
ACS medicinal chemistry letters, 5(10), 1088-1093 (2014-10-15)
A-1155463, a highly potent and selective BCL-XL inhibitor, was discovered through nuclear magnetic resonance (NMR) fragment screening and structure-based design. This compound is substantially more potent against BCL-XL-dependent cell lines relative to our recently reported inhibitor, WEHI-539, while possessing none
Anne Slomp et al.
Blood advances, 3(24), 4202-4214 (2019-12-20)
Prosurvival BCL-2 family proteins are potent inhibitors of apoptosis and often overexpressed in lymphoid malignancies. In multiple myeloma (MM), MCL-1 expression contributes to survival of malignant plasma cells, and overexpression correlates with poor prognosis. In this study, we investigated whether
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