SML3006

ICCB-19 Hydrochloride

≥98% (HPLC)

• 동의어(들): N-Cycloheptyl-2-[(4,5-dihydro-1H-imidazol-2-yl)thio]acetamide hydrochloride
• 실험식(Hill 표기법): C₁₂H₂₁N₃OS · HCl
• CAS Number: 1803605-68-6
• Molecular Weight: 291.84
• MDL number: MFCD28145281
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 저장 조건: desiccated
• 색상: white to beige
• solubility: DMSO: 2 mg/mL, clear
• 저장 온도: 2-8°C
• SMILES string: O=C(NC1CCCCCC1)CSC2=NCCN2.Cl
• InChI key: TZICOTBZKPHMMK-UHFFFAOYSA-N

설명

생화학적/생리학적 작용

ICCB-19 is a cell penetrant apoptosis inhibitor that activates autophagy leading to restoration of cellular homeostasis in cells with accumulated mutant tau, α-synuclein, or huntingtin. ICCB-19 potently and selectively inhibits TRADD. It binds to the N-terminal TRAF2-binding domain of TRADD (TRADD-N). Apparently ICCB-19 releases cIAP1/2 or TRAF2 from TRADD thus promoting the K63-linked ubiquitination of beclin 1.

cell penetrant apoptosis inhibitor that activates autophagy that potently and selectively inhibits TRADD

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable