모든 사진(1)
About This Item
실험식(Hill 표기법):
C14H11N3OS
CAS Number:
Molecular Weight:
269.32
MDL number:
UNSPSC 코드:
12352200
NACRES:
NA.77
추천 제품
분석
≥98% (HPLC)
양식
powder
색상
white to beige
solubility
DMSO: 2 mg/mL, clear
저장 온도
2-8°C
SMILES string
OC1=CC(NC2=NC(C3=NC=CC=C3)=CS2)=CC=C1
InChI key
GIGNWEDIMLUWCT-UHFFFAOYSA-N
생화학적/생리학적 작용
KCC-07 is a brain penetrant, potent and selective inhibitor of MBD2 (methyl-CpG-binding domain protein 2) that inhibits binding of MBD2 to methylated DNA and activates brain specific angiogenesis inhibitor 1 (BAI1) inducing anti-proliferative BAI1/p53/p21 signaling. KCC-07 inhibits medulloblastoma cell proliferation, and inhibits tumor growth in mice xenograft models of medulloblastoma.
brain penetrant, potent and selective inhibitor of MBD2 that inducing anti-proliferative BAI1/p53/p21 signaling
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
Dan Zhu et al.
Cancer cell, 33(6), 1004-1016 (2018-06-13)
Adhesion G protein-coupled receptors (ADGRs) encompass 33 human transmembrane proteins with long N termini involved in cell-cell and cell-matrix interactions. We show the ADGRB1 gene, which encodes Brain-specific angiogenesis inhibitor 1 (BAI1), is epigenetically silenced in medulloblastomas (MBs) through a methyl-CpG
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