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Merck
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주요 문서

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SML2313

Sigma-Aldrich

Higenamine hydrochloride

≥95% (HPLC)

동의어(들):

Higenamine hydrochloride, (RS)-Norcoclaurine hydrochloride, (±)-1,2,3,4-tetrahydro-1-[(4-hydroxyphenyl)methyl]-6,7-Isoquinolinediol hydrochloride, (±)-Demethylcoclaurine, (±)-Norcoclaurine hydrochloride, (±)-O-Demethylcoclaurine hydrochloride, 1,2,3,4-Tetrahydro-1-[(4-hydroxyphenyl)methyl]-6,7-isoquinolinediol hydrochloride, dl-Demethylcoclaurine hydrochloride, (±)-Demethylcoclaurine hydrochloride

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모든 사진(1)

About This Item

실험식(Hill 표기법):
C16H17NO3 · HCl
CAS Number:
11041-94-4
Molecular Weight:
307.77
MDL number:
MFCD01717353
UNSPSC 코드:
12352116
NACRES:
NA.77

분석

≥95% (HPLC)

양식

powder

저장 조건

desiccated

색상

white to beige

solubility

H2O: 2 mg/mL, clear (warmed)

저장 온도

2-8°C

SMILES string

OC1=C(O)C=C(C(CC2=CC=C(O)C=C2)NCC3)C3=C1.Cl

InChI

1S/C16H17NO3.ClH/c18-12-3-1-10(2-4-12)7-14-13-9-16(20)15(19)8-11(13)5-6-17-14;/h1-4,8-9,14,17-20H,5-7H2;1H

InChI key

SWWQQSDRUYSMAR-UHFFFAOYSA-N

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생화학적/생리학적 작용

Higenamine is an anti-inflammatory agent that protects cells from oxidant injury. Higenamine is a pharmacological modulator of heme oxygenase 1(HO-1). It also displays agonist activity at adrenergic β2 receptor.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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시험 성적서(COA)

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문서 라이브러리 방문

Wenjiang Duan et al.
Experimental and therapeutic medicine, 12(5), 3107-3112 (2016-11-25)
Existing in Ranunculaceae Aconitum and tomato, with the chemical name 1-phydroxybenzyl-1,2,3,4-tetrahy-droisoquinoline, higenamine is widely distributed in China. Higenamine's anti-inflammatory, antioxidant and anti-apoptotic effects have been identified in previous studies. The present study attempted to determine the protective effect of higenamine
Eisuke Kato et al.
Bioorganic & medicinal chemistry, 25(24), 6412-6416 (2017-10-27)
β2-Adrenergic receptor (β2AR) agonists are employed as bronchodilators to treat pulmonary disorders, but are attracting attention for their modulation of glucose handling and energy expenditure. Higenamine is a tetrahydroisoquinoline present in several plant species and has β2AR agonist activity, but
Xiaoxia An et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 95, 1710-1717 (2017-09-30)
Diabetic gastroparesis (DGP) is a common complication of diabetes mellitus (DM). The numerous clinical symptoms of DGP and the great cost on the treatment of DGP seriously lowered the patients' life quality. However, the pathogenic mechanism of DGP is still

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