SML2286
BIIL260 hydrochloride
≥98% (HPLC)
동의어(들):
4-(3-{4-[1-(4-Hydroxy-phenyl)-1-methyl-ethyl]-phenoxymethyl}-benzyloxy)-benzamidine hydrochloride, BIIL 260 hydrochloride, BIIL-260 hydrochloride
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모든 사진(1)
About This Item
실험식(Hill 표기법):
C30H30N2O3 · xHCl
CAS Number:
Molecular Weight:
466.57 (free base basis)
UNSPSC 코드:
12352200
NACRES:
NA.77
추천 제품
분석
≥98% (HPLC)
형태
powder
저장 조건
desiccated
색상
white to beige
solubility
DMSO: 2 mg/mL, clear
저장 온도
2-8°C
InChI
1S/C30H30N2O3/c1-30(2,24-8-12-26(33)13-9-24)25-10-16-28(17-11-25)35-20-22-5-3-4-21(18-22)19-34-27-14-6-23(7-15-27)29(31)32/h3-18,33H,19-20H2,1-2H3,(H3,31,32)
InChI key
MBLJFKQACMILLC-UHFFFAOYSA-N
생화학적/생리학적 작용
BIIL260 is a selective and potent leukotriene B4 (BLT1) receptor antagonist with a Ki value of 1.8 nM in human U937 cells. BIIL260 was used found to act as an inverse agonist, stabilizing the inactive state of BLT1.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Kazuyuki Nakagome et al.
Respirology (Carlton, Vic.), 22(5), 913-921 (2017-02-01)
Acute eosinophilic pneumonia (AEP) is characterized by a massive pulmonary infiltration of eosinophils. Mechanisms regulating the selective accumulation of eosinophils in AEP have not been fully established. The objective of this study was to evaluate the mechanisms of eosinophil accumulation
Tetsuya Hori et al.
Nature chemical biology, 14(3), 262-269 (2018-01-09)
Most G-protein-coupled receptors (GPCRs) are stabilized in common in the inactive state by the formation of the sodium ion-centered water cluster with the conserved Asp2.50 inside the seven-transmembrane domain. We determined the crystal structure of the leukotriene B4 (LTB4) receptor
F W Birke et al.
The Journal of pharmacology and experimental therapeutics, 297(1), 458-466 (2001-03-22)
BIIL 284 is a new LTB(4) receptor antagonist. It is a prodrug and has negligible binding to the LTB(4) receptor. However, ubiquitous esterases metabolize BIIL 284 to the active metabolites BIIL 260 and BIIL 315, the glucuronidated form of BIIL
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